Dave Bridges

Position
Assistant Professor, Department of Nutritional Sciences, University of Michigan since 2016-06-01. (1 year, 3 months). Show previous positions.
Degrees
B.Sc. (Biological Sciences, University of Calgary).
Ph.D. (Biological Sciences, University of Calgary).
Email
davebrid@umich.edu
Phone
7347641266
ORCID Identification Number
0000-0002-5334-972X
Bio
My team wants to understand the molecular networks that lie at the intersection between metabolism and health. I did my undergraduate and doctoral training in Biochemistry at the University of Calgary, in Calgary, Alberta, Canada followed by a fellowship with Dr. Alan Saltiel at the University of Michigan. During that time we used several model systems including yeast, flies and mice to elucidate a variety of novel aspects of metabolic regulation. My team studies the molecular, cellular and physiological changes associated with obesity. We are particularly interested in the role of the central nutrient responsive protein kinase mTORC1, how it is altered in weight gain and how its activation affects obesity related co-morbidities. With a better understanding of the molecular mechanisms underlying obesity, we hope to better prevent and treat obesity in the future.
Social Media
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Publications

Michael Keufner, Kevin Pham, JeAnna Redd, Erin Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshal Elam and Edwards Park. Secretory phospholipase A2 group IIA (PLA2G2A) modulates insulin sensitivity and metabolism. 2017. Journal of Lipid Research Full Text Details.
Suriyan Ponnusamy, Ryan Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel Johnson, Maron Barrett, Nikki Koehler, Mayra Star, Erin Stephenson, Dave Bridges, Stephania Cormier, Lawrence Pfeffer and Ramesh Narayanan. Androgen Receptor Agonists Increase Lean Mass, Improve Cardiopulmonary Functions, and Extend Survival in Preclinical Models of Duchenne Muscular Dystrophy 2017. Human Molecular Genetics Full Text Details.
Suriyan Ponnusamy, Quynh Tran, Thirumagal Thiyagarajan, Duane Miller, Dave Bridges and Ramesh Narayanan. An Estrogen Receptor b-Selective Agonist Inhibits Non-Alcoholic Steatohepatitis (NASH) in Preclinical Models by Regulating Bile Acid and Xenobiotic Receptors 2017. Experimental Biology and Medicine 242(6):606-616 Full Text Details.
Suriyan Ponnusamy, Quynh Tran, Innocence Harvey, Heather Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel Johnson, James Dalton, Ryan Sullivan, Duane Miller, Dave Bridges and Ramesh Narayanan. Pharmacologic activation of estrogen receptor-beta; increases mitochondrial function, energy expenditure, and brown adipose tissue. 2017. FASEB Journal 31(1):266-281 Full Text Details.
Alysse Charrier, Li Wang, Erin Stephenson, Siddharth Gantha, Chih-wei Ko, Colleen Croninger, Dave Bridges and David Buchner. Zinc finger protein 407 overexpression upregulates PPAR-target gene expression and improves glucose homeostasis in mice. 2016. American Journal of Physiology - Endocrinology and Metabolism 311(5):E869-E880 Full Text Details.
Erin Stephenson, Sridhar Jaligama, Alyse Ragauskas, JeAnna Redd, Jyothi Parvathareddy, Matthew Peloquin, Jordy Saravia, Joan Han, Stephania Cormier and Dave Bridges. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
Qingming Dong, Francesco Giorgianni, Sarka Beranova-Giorgianni, Xiong Deng, Robert O'Meally, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degrada 2015. Bioscience Reports 36(1):e00284 Full Text Details.
Nora Urraca, R. Menon, I. El-Iyachi, Sarita Goorha, Colleen Valdez, Quynh Tran, Reese Scroggs, G. Miranda-Carboni , Martin Donaldson, Dave Bridges and Lawrence Reiter. Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders. 2015. Stem Cell Research 15(3):722-30 Full Text Details.
C. Song, K. Ghafoor, H. Ghafoor, N. Kahn, S. Thirunavukkarasu, B. Jennings, A. Estes, S. Zaidi, Dave Bridges, Patrick Tso, F. Gonzalez and K. Malik. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. 2016. Hypertension 67(1):206-13 Full Text Details.
Xiong Deng, Qingming Dong, Dave Bridges, Rajendra Raghow, Edwards Park and Marshal Elam. Docosahexaenoic Acid Inhibits Proteolytic Processing of Sterol Regulatory Element-binding Protein-1c (SREBP-1c) via Activation of AMP-activated Kinase 2015. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 185(12):1521-9 Full Text Details.
Irit Hochberg, Innocence Harvey, Quynh Tran, Erin Stephenson, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. 2015. Journal of Molecular Endocrinology 55(2):81-94 Full Text Details.
Irit Hochberg, Quynh Tran, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. 2015. PLOS One 10(6):e0129359 Full Text Details.
David Buchner, Alysse Charrier, Ethan Srinivasan, Li Wang, Michelle Paulsen, Mats Ljungman, Alan Saltiel and Dave Bridges. Zinc Finger Protein 407 (ZFP407) Regulates Insulin-Stimulated Glucose Uptake and Glucose Transporter 4 (Glut4) mRNA. 2015. The Journal of biological chemistry 290(10):6376-86 Full Text Details.
Dave Bridges and Alan Saltiel. Phosphoinositides: Key Modulators of Energy Metabolism 2014. Biochimica and Biophysica Acta - Molecular and Cell Biology of Lipids 1851(6):857-866 Full Text Details.
Qingming Dong, Francesco Giorgianni, Xiong Deng, Sarka Beranova-Giorgianni, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Phosphorylation of Sterol Regulatory Element Binding Protein-1a by Protein Kinase A (PKA) Regulates Transcriptional Activity 2014. Biochemical and Biophysical Research Communications 449(4):449-54 Full Text Details.
Anne Morrow, Mohsen Amir Alipour, Dave Bridges, Alan Saltiel, Zemin Yao and Jonathan Lee. The lipid kinase PI4KIIIbeta is highly expressed in breast tumours and activates Akt in cooperation with Rab11a. 2014. Molecular Cancer Research 12(10):1492-508 Full Text Details.
Natsuko JIn, Kai Mao, Yui Jin, Gela Tevadze, Emily Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan Saltiel, Daniel Klionsky and Lois Weisman. Roles for PI(3,5)P2 in nutrient sensing through TORC1 2014. Molecular Biology of the Cell 25(7):1171-85 Full Text Details.
Binbin Lu, Dave Bridges, Yemen Yang, Kaleigh Fisher, Alan Cheng, Louise Chang, Zhuoxian Meng, Jiande Lin, Michael Downes, Ruth Yu, Christopher Liddle, Ronald Evans and Alan Saltiel. Metabolic Crosstalk: molecular links between glycogen and lipid metabolism in obesity. 2014. Diabetes 63(9):2935-48 Full Text Details.
Tsukasa Suzuki, Dave Bridges, Daisuke Nakada, Georgios Skiniotis, Sean Morrison, Jiande Lin, Alan Saltiel and Ken Inoki. Inhibition of AMPK catabolic action by GSK3. 2013. Molecular cell 50(3):407-19 Full Text Details.
Sergey Zolov, Dave Bridges, Yanling Zhang, Wei-Wei Li, Ellen Riehle, Rakesh Verma, Guy Lenk, Kimber Converso-Baran, Thomas Weide, Roger Albin, Alan Saltiel, Miriam Meisler, Mark Russell and Lois Weisman. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. 2012. Proceedings of the National Academy of Sciences of the United States of America 109(43):17472-7 Full Text Details.
Dave Bridges and Alan Saltiel. Phosphoinositides in insulin action and diabetes. 2012. Current topics in microbiology and immunology 362:61-85 Full Text Details.
Dave Bridges, Louise Chang, Irfan Lodhi, Natalie Clark and Alan Saltiel. TC10 is regulated by caveolin in 3T3-L1 adipocytes. 2012. PLOS One 7(8):e42451 Full Text Details.
Dave Bridges, Kaleigh Fisher, Sergey Zolov, Tingting Xiong, Ken Inoki, Lois Weisman and Alan Saltiel. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. 2012. The Journal of biological chemistry 287(25):20913-21 Full Text Details.
Dave Bridges, Jing-Tyan Ma, Sujin Park, Ken Inoki, Lois Weisman and Alan Saltiel. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. 2012. Molecular biology of the cell 23(15):2955-62 Full Text Details.
Bernat Baeza-Raja, Pingping Li, Natacha Le Moan, Benjamin Sachs, Christian Schachtrup, Dimitrios Davalos, Eirini Vagena, Dave Bridges, Choel Kim, Alan Saltiel, Jerrold Olefsky and Katerina Akassoglou. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. 2012. Proceedings of the National Academy of Sciences of the United States of America 109(15):5838-43 Full Text Details.
Irfan Lodhi, Dave Bridges, Shian-Huey Chiang, Yanling Zhang, Alan Cheng, Lynn Geletka, Lois Weisman and Alan Saltiel. Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. 2008. Molecular biology of the cell 19(7):2718-28 Full Text Details.
Dave Bridges, Justin MacDonald, Brian Wadzinski and Greg Moorhead. Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. 2006. Biochemical and biophysical research communications 346(1):351-7 Full Text Details.
Dave Bridges and Greg Moorhead. 14-3-3 proteins: a number of functions for a numbered protein (2005 Update). 2005. Science's STKE : signal transduction knowledge environment 2005(296):re10 Full Text Details.
Dave Bridges and Greg Moorhead. 14-3-3 proteins: a number of functions for a numbered protein. 2004. Science's STKE : signal transduction knowledge environment 2004(242):re10 Full Text Details.
Greg Moorhead, Sarah Meek, Pauline Douglas, Dave Bridges, Catherine Smith, Nick Morrice and Carol MacKintosh. Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays. 2003. European journal of biochemistry 270(6):1356-62 Full Text Details.
Hue Tran, Dave Bridges, Annegret Ulke and Greg Moorhead. Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei. 2002. Biochemistry and cell biology 80(6):811-5 Full Text Details.
Darin Fogg, Dave Bridges, Kitty Cheung, Geetha Kassam, Nolan Filipenko, Michael Nesheim, Kyu-Sil Choi, Sandra Fitzpatrick and David Waisman. The p11 subunit of annexin II heterotetramer is regulated by basic carboxypeptidase. 2002. Biochemistry 41(15):4953-61 Full Text Details.