Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice

, Innocence Harvey, , Carol Davis, , Susan Brooks and

Biomedicines 2020. 8: 420.

Abstract

Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength. In this work, we evaluated whether a mouse model with pre-existing diet-induced obesity had altered glucocorticoid responsiveness. We observed that all animals treated with the synthetic glucocorticoid dexamethasone had reduced strength, but that obesity exacerbated this effect. These changes were concordant with more pronounced reductions in muscle size, particularly in Type II muscle fibers, and potentiated induction of atrogene expression in the obese mice relative to lean mice. Furthermore, we show that the reductions in lean mass do not fully account for the dexamethasone-induced insulin resistance observed in these mice. Together, these data suggest that obesity potentiates glucocorticoid-induced muscle atrophy.

Author Contributions

Laura Gunder

Conceptualization Data Curation Formal Analysis Investigation Validation Visualization Writing - Original Draft Writing - Review and Editing

Innocence Harvey

Conceptualization Data Curation Formal Analysis Investigation Validation Visualization Writing - Review and Editing

JeAnna Redd

Investigation Methodology Writing - Review and Editing

Carol Davis

Investigation

Ayat AL-Tamimi

Investigation

Susan Brooks

Conceptualization Investigation Methodology Resources Writing - Review and Editing

Dave Bridges

Conceptualization Data Curation Formal Analysis Funding Acquisition Investigation Methodology Project Administration Resources Software Validation Visualization Writing - Review and Editing

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