Welcome to the Bridges Lab

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We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

Nora Urraca, Kevin Hope, A. Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh Tran, Silva Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges and Lawrence Reiter. Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons 2018. Molecular Autism 9(6): Full Text Details.
Michael Keufner, Kevin Pham, JeAnna Redd, Erin Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshal Elam and Edwards Park. Secretory phospholipase A2 group IIA (PLA2G2A) modulates insulin sensitivity and metabolism. 2017. Journal of Lipid Research Full Text Details.
Suriyan Ponnusamy, Ryan Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel Johnson, Maron Barrett, Nikki Koehler, Mayra Star, Erin Stephenson, Dave Bridges, Stephania Cormier, Lawrence Pfeffer and Ramesh Narayanan. Androgen Receptor Agonists Increase Lean Mass, Improve Cardiopulmonary Functions, and Extend Survival in Preclinical Models of Duchenne Muscular Dystrophy 2017. Human Molecular Genetics Full Text Details.
Suriyan Ponnusamy, Quynh Tran, Thirumagal Thiyagarajan, Duane Miller, Dave Bridges and Ramesh Narayanan. An Estrogen Receptor b-Selective Agonist Inhibits Non-Alcoholic Steatohepatitis (NASH) in Preclinical Models by Regulating Bile Acid and Xenobiotic Receptors 2017. Experimental Biology and Medicine 242(6):606-616 Full Text Details.
Suriyan Ponnusamy, Quynh Tran, Innocence Harvey, Heather Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel Johnson, James Dalton, Ryan Sullivan, Duane Miller, Dave Bridges and Ramesh Narayanan. Pharmacologic activation of estrogen receptor-beta; increases mitochondrial function, energy expenditure, and brown adipose tissue. 2017. FASEB Journal 31(1):266-281 Full Text Details.
Alysse Charrier, Li Wang, Erin Stephenson, Siddharth Gantha, Chih-wei Ko, Colleen Croninger, Dave Bridges and David Buchner. Zinc finger protein 407 overexpression upregulates PPAR-target gene expression and improves glucose homeostasis in mice. 2016. American Journal of Physiology - Endocrinology and Metabolism 311(5):E869-E880 Full Text Details.
Erin Stephenson, Sridhar Jaligama, Alyse Ragauskas, JeAnna Redd, Jyothi Parvathareddy, Matthew Peloquin, Jordy Saravia, Joan Han, Stephania Cormier and Dave Bridges. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
  • Muñiz Pedrogo, D. A. et al. Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet. Mayo Clin. Proc. 93, 1104–1110 (2018). 10.1016/j.mayocp.2018.02.019
  • Ben-Zvi, D. et al. Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species. Cell Metab. 28, 310–323.e6 (2018). 10.1016/j.cmet.2018.06.004
  • Macedo, A. G. et al. Time-course changes of catabolic proteins following muscle atrophy induced by dexamethasone. Steroids 107, 30–36 (2016). 10.1016/j.steroids.2015.12.016
  • Krishnan, S. et al. A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes. Am. J. Clin. Nutr. 108, 266–278 (2018). 10.1093/ajcn/nqy113
  • Langdown, M. L. & Sugden, M. C. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Mol. Cell. Endocrinol. 185, 109–117 (2001). 10.1016/S0303-7207(01)00629-3