Welcome to the Bridges Lab

We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

Erin Stephenson, Alyse Ragauskas, Sridhar Jaligama, JeAnna Redd, Jyothi Parvathareddy, Matthew Peloquin, Jordy Saravia, Joan Han, Stephania Cormier and Dave Bridges. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
Qingming Dong, Francesco Giorgianni, Sarka Beranova-Giorgianni, Xiong Deng, Robert O'Meally, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degrada 2015. Bioscience Reports Full Text Details.
Nora Urraca, R. Menon, I. El-Iyachi, Sarita Goorha, Colleen Valdez, Quynh Tran, Reese Scroggs, G. Miranda-Carboni , Martin Donaldson, Dave Bridges and Lawrence Reiter. Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders. 2015. Stem Cell Research 15(3):722-30 Full Text Details.
C. Song, K. Ghafoor, H. Ghafoor, N. Kahn, S. Thirunavukkarasu, B. Jennings, A. Estes, S. Zaidi, Dave Bridges, Patrick Tso, F. Gonzalez and K. Malik. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. 2015. Hypertension Full Text Details.
Xiong Deng, Qingming Dong, Dave Bridges, Rajendra Raghow, Edwards Park and Marshal Elam. Docosahexaenoic Acid Inhibits Proteolytic Processing of Sterol Regulatory Element-binding Protein-1c (SREBP-1c) via Activation of AMP-activated Kinase 2015. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids In Press: Full Text Details.
Irit Hochberg, Innocence Harvey, Quynh Tran, Erin Stephenson, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. 2015. Journal of Molecular Endocrinology 55(2):81-94 Full Text Details.
Irit Hochberg, Quynh Tran, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. 2015. PLOS One 10(6):e0129359 Full Text Details.
Izzy Hatfield, Innocence Harvey, Erika Yates, JeAnna Redd, Lawrence Reiter and Dave Bridges. The role of TORC1 in muscle development in Drosophila. 2015. Scientific Reports 5:9676 Full Text Details.
David Buchner, Alysse Charrier, Ethan Srinivasan, Li Wang, Michelle Paulsen, Mats Ljungman, Dave Bridges and Alan Saltiel. Zinc Finger Protein 407 (ZFP407) Regulates Insulin-Stimulated Glucose Uptake and Glucose Transporter 4 (Glut4) mRNA. 2015. The Journal of biological chemistry 290(10):6376-86 Full Text Details.