Welcome to the Bridges Lab
We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.
The members of our group.
The projects we are working on.
Papers we have published.
Where we are located.
How to contact us.
Innocence Harvey,
Erin Stephenson,
JeAnna Redd,
Quynh Tran,
Irit Hochberg,
Nathan Qi
and Dave Bridges.
Glucocorticoid-Induced Metabolic Disturbances are Exacerbated in Obesity 2017. bioRxiv Full Text Details. Preprint
Michael Keufner,
Kevin Pham,
JeAnna Redd,
Erin Stephenson,
Innocence Harvey,
Xiong Deng,
Dave Bridges,
Eric Boilard,
Marshal Elam
and Edwards Park.
Secretory phospholipase A2 group IIA (PLA2G2A) modulates insulin sensitivity and metabolism. 2017. Journal of Lipid Research Full Text Details.
Suriyan Ponnusamy,
Ryan Sullivan,
Dahui You,
Nadeem Zafar,
Chuan He Yang,
Thirumagal Thiyagarajan,
Daniel Johnson,
Maron Barrett,
Nikki Koehler,
Mayra Star,
Erin Stephenson,
Dave Bridges,
Stephania Cormier,
Lawrence Pfeffer
and Ramesh Narayanan.
Androgen Receptor Agonists Increase Lean Mass, Improve Cardiopulmonary Functions, and Extend Survival in Preclinical Models of Duchenne Muscular Dystrophy 2017. Human Molecular Genetics Full Text Details.
Dave Bridges
Weight loss effects of Methotrexate and Cyclophosphamide. 2017. Oncotarget 8(3):5640 Full Text Details.
Suriyan Ponnusamy,
Quynh Tran,
Thirumagal Thiyagarajan,
Duane Miller,
Dave Bridges
and Ramesh Narayanan.
An Estrogen Receptor b-Selective Agonist Inhibits Non-Alcoholic Steatohepatitis (NASH) in Preclinical Models by Regulating Bile Acid and Xenobiotic Receptors 2017. Experimental Biology and Medicine 242(6):606-616 Full Text Details.
Suriyan Ponnusamy,
Quynh Tran,
Innocence Harvey,
Heather Smallwood,
Thirumagal Thiyagarajan,
Souvik Banerjee,
Daniel Johnson,
James Dalton,
Ryan Sullivan,
Duane Miller,
Dave Bridges
and Ramesh Narayanan.
Pharmacologic activation of estrogen receptor-beta; increases mitochondrial function, energy expenditure, and brown adipose tissue. 2017. FASEB Journal 31(1):266-281 Full Text Details.
Alysse Charrier,
Li Wang,
Erin Stephenson,
Siddharth Gantha,
Chih-wei Ko,
Colleen Croninger,
Dave Bridges
and David Buchner.
Zinc finger protein 407 overexpression upregulates PPAR-target gene expression and improves glucose homeostasis in mice. 2016. American Journal of Physiology - Endocrinology and Metabolism 311(5):E869-E880 Full Text Details.
Erin Stephenson,
Sridhar Jaligama,
Alyse Ragauskas,
JeAnna Redd,
Jyothi Parvathareddy,
Matthew Peloquin,
Jordy Saravia,
Joan Han,
Stephania Cormier
and Dave Bridges.
Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
Daniel Klionsky
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016. Autophagy 12(1):1-222 Full Text Details.
Qingming Dong,
Francesco Giorgianni,
Sarka Beranova-Giorgianni,
Xiong Deng,
Robert O'Meally,
Dave Bridges,
Edwards Park,
Marshal Elam
and Rajendra Raghow.
Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degrada 2015. Bioscience Reports 36(1):e00284 Full Text Details.
- Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.
- Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity
- SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
- Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism.
- Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation