Welcome to the Bridges Lab

Bridges Lab Photo

We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

  • Laura Saslow, Alison O'Brien, Kaitlyn Raymond, Hovig Bayandorian, Deanna Marriott, Judith Moskowitz, Jennifer Daubenmier, Dave Bridges, Cody Cousineau and Dina Griauzde. Feasibility and acceptability of an online multicomponent very low-carbohydrate intervention in young adult women with obesity: a pilot study 2024. Pilot and Feasibility Studies 10(1):102 Full Text Details.
  • Michael Saul, Elizabeth Litkowski, Niran Hadad, Amy Dunn, Stephanie Boas, Jon Wilcox, Julia Robbins, Yiyang Wu, Vivek Philip, Gennefer Merrihew, Jea Park, Philip De Jager, Dave Bridges, Vilas Menon, David Bennett, Timothy Hohman, Michael MacCoss and Catherine Kaczorowski. Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population 2024. bioRxiv Full Text Details. Preprint
  • Click here for a full list of papers.

    2025 Journal Club Articles

  • Zhao Q, Yokomizo S, Perle SJ, Lee YF, Zhou H, Miller MR, Li H, Gerashchenko D, Gomperts SN, Bacskai BJ, Kastanenka KV. Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer's disease mouse model. Sci Rep. 2024 Oct 4;14(1):23044. doi: 10.1038/s41598-024-73082-8. PMID: 39362954; PMCID: PMC11450172. 10.1038/s41598-024-73082-8. Discussed on Feb. 12, 2025
  • Reed JN, Hasan F, Karkar A, Banka D, Hinkle J, Shastri P, Srivastava N, Scherping SC, Newkirk SE, Ferris HA, Kundu BK, Kranz S, Civelek M, Keller SR. Combined effects of genetic background and diet on mouse metabolism and gene expression. iScience. 2024 Nov 4;27(12):111323. doi: 10.1016/j.isci.2024.111323. PMID: 39640571; PMCID: PMC11617257. 10.1016/j.isci.2024.111323. Discussed on Jan. 29, 2025
  • 2024 Journal Club Articles

  • Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J, Li F, Xiong W, Rao S, Xiang Q, Shi W, Song T, Deng J, Yin Y, Tan C. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci Adv. 2023 Nov 3;9(44):eadi7337. doi: 10.1126/sciadv.adi7337. Epub 2023 Nov 3. PMID: 37922350; PMCID: PMC10624355. 10.1126/sciadv.adi7337. Discussed on Nov. 11, 2024
  • Machado H, Hofer P, Zechner R, Smith TK, Figueiredo LM. Adipocyte lipolysis protects mice against Trypanosoma brucei infection. Nat Microbiol. 2023 Nov;8(11):2020-2032. doi: 10.1038/s41564-023-01496-7. Epub 2023 Oct 12. PMID: 37828246; PMCID: PMC10627827. https://doi.org/10.1038/s41564-023-01496-7. Discussed on Oct. 28, 2024
  • Sonsalla MM, Babygirija R, Johnson M, Cai S, Cole M, Yeh CY, Grunow I, Liu Y, Vertein D, Calubag MF, Trautman ME, Green CL, Rigby MJ, Puglielli L, Lamming DW. Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. Geroscience. 2024 Sep 14. doi: 10.1007/s11357-024-01337-3. Epub ahead of print. PMID: 39271570. 10.1007/s11357-024-01337-3. Discussed on Sept. 30, 2024
  • Click here for a full list of journal club articles.