Welcome to the Bridges Lab
We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.
The members of our group.
The projects we are working on.
Papers we have published.
Where we are located.
How to contact us.
Alysse Charrier,
Li Wang,
Erin Stephenson,
Siddharth Gantha,
Chih-wei Ko,
Colleen Croninger,
Dave Bridges
and David Buchner.
Zinc finger protein 407 overexpression upregulates PPAR-target gene expression and improves glucose homeostasis in mice. 2016. American Journal of Physiology - Endocrinology and Metabolism Full Text Details.
Erin Stephenson,
Alyse Ragauskas,
Sridhar Jaligama,
JeAnna Redd,
Jyothi Parvathareddy,
Matthew Peloquin,
Jordy Saravia,
Joan Han,
Stephania Cormier
and Dave Bridges.
Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
Daniel Klionsky
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016. Autophagy 12(1):1-222 Full Text Details.
Qingming Dong,
Francesco Giorgianni,
Sarka Beranova-Giorgianni,
Xiong Deng,
Robert O'Meally,
Dave Bridges,
Edwards Park,
Marshal Elam
and Rajendra Raghow.
Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degrada 2015. Bioscience Reports Full Text Details.
Nora Urraca,
R. Menon,
I. El-Iyachi,
Sarita Goorha,
Colleen Valdez,
Quynh Tran,
Reese Scroggs,
G. Miranda-Carboni ,
Martin Donaldson,
Dave Bridges
and Lawrence Reiter.
Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders. 2015. Stem Cell Research 15(3):722-30 Full Text Details.
C. Song,
K. Ghafoor,
H. Ghafoor,
N. Kahn,
S. Thirunavukkarasu,
B. Jennings,
A. Estes,
S. Zaidi,
Dave Bridges,
Patrick Tso,
F. Gonzalez
and K. Malik.
Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. 2015. Hypertension Full Text Details.
Xiong Deng,
Qingming Dong,
Dave Bridges,
Rajendra Raghow,
Edwards Park
and Marshal Elam.
Docosahexaenoic Acid Inhibits Proteolytic Processing of Sterol Regulatory Element-binding Protein-1c (SREBP-1c) via Activation of AMP-activated Kinase 2015. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids In Press: Full Text Details.
Irit Hochberg,
Innocence Harvey,
Quynh Tran,
Erin Stephenson,
Ariel Barkan,
Alan Saltiel,
William Chandler
and Dave Bridges.
Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. 2015. Journal of Molecular Endocrinology 55(2):81-94 Full Text Details.
Irit Hochberg,
Quynh Tran,
Ariel Barkan,
Alan Saltiel,
William Chandler
and Dave Bridges.
Gene Expression Signature in Adipose Tissue of Acromegaly Patients. 2015. PLOS One 10(6):e0129359 Full Text Details.
Izzy Hatfield,
Innocence Harvey,
Erika Yates,
JeAnna Redd,
Lawrence Reiter
and Dave Bridges.
The role of TORC1 in muscle development in Drosophila. 2015. Scientific Reports 5:9676 Full Text Details.
- Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.
- Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity
- SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta.
- Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism.
- Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation