Welcome to the Bridges Lab

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We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

Qingming Dong, Michael Keufner, Xiong Deng, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats. 2018. Biology of Sex Differences 9(1):40 Full Text Details.
John Bissler, Fahad Zadjali, Dave Bridges, Aristotelis Astrindis, Sharon Barone, Ying Yao, JeAnna Redd, Brian Siroky, Yanqing Wang, Joel Finley, Michael Rusniak, Heinz Baumann, Kamyar Zahedi, Kenneth Gross and Manoocher Soleimani. Tuberous sclerosis complex exhibits a new renal cystogenic mechanism. 2019. Physiological Reports 7(2):e13983 Full Text Details.
Amanda Stayton, Shelby Fox, Erin Stephenson, Clint Kinney, Noor Alshibli, Charles Gomes, Joseph Pierre, Michelle Puchowicz, Dave Bridges, Keri Martinowich, Joan Han, Liam McAllan, Kristen Maynard and Alisha Kardian. Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice 2018. American Journal of Physiology - Endocrinology and Metabolism 315(6):E1168-E1184 Full Text Details.
Nora Urraca, Kevin Hope, A. Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh Tran, Silva Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges and Lawrence Reiter. Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons 2018. Molecular Autism 9(6): Full Text Details.
Michael Keufner, Kevin Pham, JeAnna Redd, Erin Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshal Elam and Edwards Park. Secretory phospholipase A2 group IIA (PLA2G2A) modulates insulin sensitivity and metabolism. 2017. Journal of Lipid Research Full Text Details.
Suriyan Ponnusamy, Ryan Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel Johnson, Maron Barrett, Nikki Koehler, Mayra Star, Erin Stephenson, Dave Bridges, Stephania Cormier, Lawrence Pfeffer and Ramesh Narayanan. Androgen Receptor Agonists Increase Lean Mass, Improve Cardiopulmonary Functions, and Extend Survival in Preclinical Models of Duchenne Muscular Dystrophy 2017. Human Molecular Genetics Full Text Details.
Suriyan Ponnusamy, Quynh Tran, Thirumagal Thiyagarajan, Duane Miller, Dave Bridges and Ramesh Narayanan. An Estrogen Receptor b-Selective Agonist Inhibits Non-Alcoholic Steatohepatitis (NASH) in Preclinical Models by Regulating Bile Acid and Xenobiotic Receptors 2017. Experimental Biology and Medicine 242(6):606-616 Full Text Details.
  • Graham AM, Rasmussen JM, Entringer S, et al. Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors. Biol Psychiatry. 2019;85(2):172-181. doi:10.1016/j.biopsych.2018.06.023. 10.1016/j.biopsych.2018.06.023
  • Wharfe MD, Mark PJ, Waddell BJ. Circadian variation in placental and hepatic clock genes in rat pregnancy. Endocrinology. 2011;152(9):3552-3560. doi:10.1210/en.2011-0081. 10.1210/en.2011-0081
  • Pattison KL, Kraschnewski JL, Lehman E, et al. Breastfeeding initiation and duration and child health outcomes in the first baby study. Prev Med (Baltim). 2019;118(March 2018):1-6. doi:10.1016/j.ypmed.2018.09.020. 10.1016/j.ypmed.2018.09.020
  • Weir T, Barbour LA, Johnson LK, et al. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018;9(1):1-12. doi:10.1038/s41467-018-06929-0. 10.1038/s41467-018-06929-0
  • H√łgild ML, Bak AM, Pedersen SB, et al. Growth hormone signaling and action in obese versus lean human subjects. Am J Physiol Metab. 2019;316(2):E333-E344. doi:10.1152/ajpendo.00431.2018. 10.1152/ajpendo.00431.2018