Welcome to the Bridges Lab

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We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

Scott Ochsner, David Abraham, Kirt Martin, Wei Ding, Apollo McOwiti, Wasula Kankanamge, Zichen Wang, Kaitlyn Andreano, Ross Hamilton, Yue Chen, Angelica Hamilton, Marin Gantner, Michael Dehart, Shijing Qu, Susan Hilsenbeck, Lauren Becnel, Dave Bridges, Avi Ma'ayan, Janice Huss, Fabio Stossi, Charles Foulds, Anastasia Kralli, Donald McDonnell and Neil McKenna. The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways 2019. Scientific Data 6(1):252 Full Text Details.
Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy Barnes, Gabrielle Steinl, Nicole Patterson, Christopher Altheim, Naveen Sharma, Ken Inoki, Gregory Cartee, Dave Bridges, Lei Yin and Diane Fingar. AMPK directly activates mTORC2 to promote cell survival during acute energetic stress 2019. Science Signaling 11(12):585 Full Text Details.
John Bissler, Fahad Zadjali, Dave Bridges, Aristotelis Astrindis, Sharon Barone, Ying Yao, JeAnna Redd, Brian Siroky, Yanqing Wang, Joel Finley, Michael Rusniak, Heinz Baumann, Kamyar Zahedi, Kenneth Gross and Manoocher Soleimani. Tuberous sclerosis complex exhibits a new renal cystogenic mechanism. 2019. Physiological Reports 7(2):e13983 Full Text Details.
Liam McAllan, Kristen Maynard, Alisha Kardian, Amanda Stayton, Shelby Fox, Erin Stephenson, Clint Kinney, Noor Alshibli, Charles Gomes, Joseph Pierre, Michelle Puchowicz, Dave Bridges, Keri Martinowich and Joan Han. Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice 2018. American Journal of Physiology - Endocrinology and Metabolism 315(6):E1168-E1184 Full Text Details.
Qingming Dong, Michael Keufner, Xiong Deng, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats. 2018. Biology of Sex Differences 9(1):40 Full Text Details.

May 2020 Journal Club Articles

  • Plessow F, Singhal V, Toth AT, Micali N, Eddy KT, Misra M. Estrogen administration improves the trajectory of eating disorder pathology in oligo-amenorrheic athletes: A randomized controlled trial. Psychoneuroendocrinology 102: 273–280, 2019. 10.1016/j.psyneuen.2018.11.013. Discussed on May 15, 2020
  • Keleher MR, Erickson K, Kechris K, Yang I V., Dabelea D, Friedman JE, Boyle KE, Jansson T. Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort. Int. J. Obes. (2020). 10.1038/s41366-020-0574-y. Discussed on May 15, 2020
  • Hall KD, Guo J, Courville AB, Boring J, Brychta R, Kong Y, Darcey V, Forde CG, Gharib AM, Gallagher I, Howard R, Joseph P V, Milley L, Ouwerkerk R, Rozga I, Schick A, Stagliano M, Torres S, Chung ST. A plant-based, low-fat diet decreases ad libitum energy intake compared to an animal-based, ketogenic diet: An inpatient randomized controlled trial. NutRxiv (2020). doi: 10.31232/osf.io/rdjfb. 10.31232/osf.io/rdjfb. Discussed on May 15, 2020
  • Meddens SFW, de Vlaming R, Bowers P, Burik CAP, Linnér RK, Lee C, Okbay A, Turley P, Rietveld CA, Fontana MA, Ghanbari M, Imamura F, McMahon G, van der Most PJ, Voortman T, Wade KH, Anderson EL, Braun KVE, Emmett PM, Esko T, Gonzalez JR, Kiefte-de Jong JC, Langenberg C, Luan J, Muka T, Ring S, Rivadeneira F, Snieder H, van Rooij FJA, Wolffenbuttel BHR, Smith GD, Franco OH, Forouhi NG, Ikram MA, Uitterlinden AG, van Vliet-Ostaptchouk J V., Wareham NJ, Cesarini D, Harden KP, Lee JJ, Benjamin DJ, Chow CC, Koellinger PD. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle. Mol. Psychiatry ( May 11, 2020). doi: 10.1038/s41380-020-0697-5. 10.1038/s41380-020-0697-5. Discussed on May 15, 2020
  • Orr SK, Dachner N, Frank L, Tarasuk V. Relation between household food insecurity and breastfeeding in Canada. Cmaj 190: E312–E319, 2018. 10.1503/cmaj.170880. Discussed on May 8, 2020