Welcome to the Bridges Lab

We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

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Recent Publications

Cody Cousineau, Detrick Snyder, JeAnna Redd, Sophia Turner, Treyton Carr and Dave Bridges. Reduced beta-hydroxybutyrate disposal after ketogenic diet feeding in mice 2024. bioRxiv Full Text Details. Preprint

Molly Mulcahy, Noura El Habbal, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice 2024. bioRxiv Full Text Details. Preprint

Michael Saul, Elizabeth Litkowski, Niran Hadad, Amy Dunn, Stephanie Boas, Jon Wilcox, Julia Robbins, Yiyang Wu, Vivek Philip, Gennefer Merrihew, Jea Park, Philip De Jager, Dave Bridges, Vilas Menon, David Bennett, Timothy Hohman, Michael MacCoss and Catherine Kaczorowski. Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population 2024. bioRxiv Full Text Details. Preprint

Cody Cousineau, Kaelin Loftus, Gary Churchill and Dave Bridges. Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice 2023. FEBS Open Biology 14(3):426-433 Full Text Details.

Molly Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice 2023. Journal of Obesity Full Text Details.

Journal Club Discussions

April 2024 Journal Club Articles

Crujeiras AB, Izquierdo AG, Primo D, Milagro FI, Sajoux I, Jácome A, Fernandez-Quintela A, Portillo MP, Martínez JA, Martinez-Olmos MA, de Luis D, Casanueva FF. Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity. Clin Nutr. 2021 Jun;40(6):3959-3972. doi: 10.1016/j.clnu.2021.05.010. Epub 2021 May 21. PMID: 34139469. 10.1016/j.clnu.2021.05.010. Discussed on April 5, 2024

March 2024 Journal Club Articles

Ryan JP, Karim HT, Aizenstein HJ, Helbling NL, Toledo FGS. Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage. 2018 May 1;171:268-276. doi: 10.1016/j.neuroimage.2018.01.024. Epub 2018 Jan 13. PMID: 29339315; PMCID: PMC5857474. 10.1016/j.neuroimage.2018.01.024. Discussed on March 29, 2024

Berry A, Collacchi B, Capoccia S, D'Urso MT, Cecchetti S, Raggi C, Sestili P, Aricò E, Pontecorvi G, Puglisi R, Ortona E, Cirulli F. Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer. Front Behav Neurosci. 2021 Jul 9;15:660738. doi: 10.3389/fnbeh.2021.660738. PMID: 34305544; PMCID: PMC8298821. 10.3389/fnbeh.2021.660738. Discussed on March 22, 2024

Moore MP, Shryack G, Alessi I, Wieschhaus N, Meers GM, Johnson SA, Wheeler AA, Ibdah JA, Parks EJ, Rector RS. Relationship Between Serum ?-Hydroxybutyrate and Hepatic Fatty Acid Oxidation in Individuals with Obesity and NAFLD. Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00336.2023. Epub ahead of print. PMID: 38381399. 10.1152/ajpendo.00336.2023. Discussed on March 15, 2024

February 2024 Journal Club Articles

Lu JF, Zhu MQ, Xia B, Zhang NN, Liu XP, Liu H, Zhang RX, Xiao JY, Yang H, Zhang YQ, Li XM, Wu JW. GDF15 is a major determinant of ketogenic diet-induced weight loss. Cell Metab. 2023 Dec 5;35(12):2165-2182.e7. doi: 10.1016/j.cmet.2023.11.003. Erratum in: Cell Metab. 2024 Feb 6;36(2):454-456. PMID: 38056430. 10.1016/j.cmet.2023.11.003. Discussed on Feb. 23, 2024