Bridges Lab Journal Club

Papers Discussed in Journal Club

These are the papers that we discussed most recently in Journal club. Click here for the complete list.
  • d’Avignon, D. A. et al. Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome. JCI Insight 3, (2018). 10.1172/JCI.INSIGHT.99762
  • Singh, A., Zapata, R. C., Pezeshki, A., Reidelberger, R. D. & Chelikani, P. K. Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat fed male rats. J. Nutr. Biochem. 1072–1074 (2018). doi:10.1016/j.jnutbio.2018.05.017 10.1016/j.jnutbio.2018.05.017
  • Song, L. et al. Prenatal high-fat diet alters placental morphology, nutrient transporter expression, and mtorc1 signaling in rat. Obesity 25, 909–919 (2017). 10.1002/oby.21821
  • Hasan, A. U. et al. PPAR? Activation Mitigates Glucocorticoid Receptor-Induced Excessive Lipolysis in Adipocytes via Homeostatic Crosstalk. J. Cell. Biochem. 1–26 (2017). doi:10.1002/jcb.26631 10.1002/jcb.26631
  • Brassard, D. et al. Saturated fats from butter but not from cheese increase HDL-Mediated cholesterol efflux capacity from J774 macrophages in men and women with abdominal obesity. J. Nutr. 148, 573–580 (2018). 10.1093/jn/nxy014
  • Altmäe, S. et al. Maternal pre-pregnancy obesity is associated with altered placental transcriptome. PLoS One 12, 1–17 (2017). 10.1371/journal.pone.0169223
  • Sengupta, S., Peterson, T. R., Laplante, M., Oh, S. & Sabatini, D. M. MTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100–1106 (2010). 10.1038/nature09584
  • Tran, C. M. et al. Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes 65, 1–35 (2016). 10.2337/db15-0502
  • Zhang, M., Sun, W., Qian, J. & Tang, Y. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid ?-oxidation and ketogenesis via activating XBP1 signaling in liver. Redox Biol. 16, 87–96 (2018). 10.1016/j.redox.2018.01.013
  • Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11, 859–871 (2006). 10.1016/j.devcel.2006.10.007

Comments on Papers

Graeme Lancaster, Katherine Langley, Nils Anton Berglund, Helene Kammoun, Saskia Reibe, Emma Estevez, Jacquelyn Weir, Natalie Mellett, Gerard Pernes, James Conway, Man Lee, Paul Timpson, Andrew Murphy, Seth Masters, Steve Gerondakis, Nenad Bartonicek, Dominik Kaczorowski, Marcel Dinger, Peter Meikle, Peter Bond and Mark Febbraio. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism 2018. Cell Metabolism Full Text Our Thoughts Details.
Choolson Jang, Sheng Hui, Wenyun Lu, Alexis Cowan, Raphael Morscher, Gina Lee, Wei Liu, Gregory Tesz, Morris Birnbaum and Joshua Rabinowitz. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids 2018. Cell Metabolism 27(2):351-361 Full Text Our Thoughts Details.
Naresh Bal, Santosh Maurya, Danesh Sopariwala, Sanjaya Sahoo, Subash Gupta, Sana Shaikh, Meghna Pant, Leslie Rowland, Eric Bombardier, Sanjeewa Goonasekera, Russel Tupling, Jeffery Molkentin and Muthu Periasamy. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. 2012. Nature Medicine 18(19):1575-9 Full Text Our Thoughts Details.
Kevin Hall, Thomas Bemis, Robert Brychta, Kong Chen, Amber Courvillle, Emma Crayner, Stephanie Goodwin, Juen Guo, Lillian Howard, Nicolas Knuth, Bernard Miller, Carla Prado, Maria Siervo, Monica Skarulis, Mary Walter, Peter Walter and Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity 2015. Cell Metabolism 22(3):427-436 Full Text Our Thoughts Details.
Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki and Ryozo Nagai. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. 2008. Nature Medicine 14(6):656-666 Full Text Our Thoughts Details.
Andrew Shin, Martin Fasshauer, Nika Filatova, Linus Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, Claudia Lindtner, Amanda Lapworth, Olga Ilkayeva, Uwe Knippschild, Anna Wolf, Ludger Shedja, Kevin Grove, Richard Smith, Wei-Jun Qian, Chrisopher Lynch, Christopher Newgard and Christophe Buettner. Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. 2014. Cell metabolism S1550-4131(14):00400-8 Full Text Our Thoughts Details.
Jingxiang Huang, O. Nelson, Heiko Jansen, Elizabeth Galbreath, Kurt Morgenstern, Jamie Gehring, Kimberly Rigano, Jae Lee, Jianhua Gong, Adam Shaywitz, Chantal Vella, Charles Robbins and Kevin Corbit. Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation 2014. Cell Metabolism 20(2):376-82 Full Text Our Thoughts Details.
Robert Koza, Larissa Nikonova, Jessica Hogan, Jong-Seop Rim, Tamra Mendoza, Christopher Faulk, Jihad Skaf and Leslie Kozak. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. 2006. PLOS Genetics 2(5):e81 Full Text Our Thoughts Details.
Xiaoyuan Xu, Ambar Grijalva, Alicja Skowronski, Marco van Eijk, Mireille J Serlie and Anthony Ferrante. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. 2014. Cell metabolism 18(6):816-30 Full Text Our Thoughts Details.
Hui Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel Squillace, Chin-Lee Wu and Brendan Manning. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. 2009. PLOS One 4(7):e6189 Full Text Our Thoughts Details.
Alexander von Wilamowitz-Moellendorff, Roger Hunter, Mar Garcia-Rocha, Li Kang, Iliana Lopez-Soldado, Louise Lantier, Kashyap Patel, Mark Peggie, Carlos Martinez-Pons, Martin Voss, Joaquim Calbo, Patricia Cohen, David Wasserman, Joan Guinovart and Kei Sakamoto. Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. 2013. Diabetes Full Text Our Thoughts Details.
Christine Longuet, Elaine Sinclair, Adriano Maida, Laurie Baggio, Marlena Maziarz, Maureen Charron and Daniel Drucker. The glucagon receptor is required for the adaptive metabolic response to fasting. 2008. Cell Metabolism 8(5):359-71 Full Text Our Thoughts Details.
Subhash Katewa, Fabio Demontis, Marysia Kolipinski, Alan Hubbard, Matthew Gill, Norbert Perrimon, Simon Melov and Pankaj Kapahi. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. 2012. Cell metabolism 16(1):97-103 Full Text Our Thoughts Details.
Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Akihiro Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi and Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. 2013. Proceedings of the National Academy of Sciences of the United States of America 110(5):1726-31 Full Text Our Thoughts Details.