Bridges Lab Journal Club

Papers Discussed in Journal Club

These are the papers that we discussed most recently in Journal club. Click here for the complete list.

    2025 Journal Club Articles

  • Zhao Q, Yokomizo S, Perle SJ, Lee YF, Zhou H, Miller MR, Li H, Gerashchenko D, Gomperts SN, Bacskai BJ, Kastanenka KV. Optogenetic targeting of cortical astrocytes selectively improves NREM sleep in an Alzheimer's disease mouse model. Sci Rep. 2024 Oct 4;14(1):23044. doi: 10.1038/s41598-024-73082-8. PMID: 39362954; PMCID: PMC11450172. 10.1038/s41598-024-73082-8. Discussed on Feb. 12, 2025
  • Reed JN, Hasan F, Karkar A, Banka D, Hinkle J, Shastri P, Srivastava N, Scherping SC, Newkirk SE, Ferris HA, Kundu BK, Kranz S, Civelek M, Keller SR. Combined effects of genetic background and diet on mouse metabolism and gene expression. iScience. 2024 Nov 4;27(12):111323. doi: 10.1016/j.isci.2024.111323. PMID: 39640571; PMCID: PMC11617257. 10.1016/j.isci.2024.111323. Discussed on Jan. 29, 2025

    • 2024 Journal Club Articles

  • Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J, Li F, Xiong W, Rao S, Xiang Q, Shi W, Song T, Deng J, Yin Y, Tan C. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci Adv. 2023 Nov 3;9(44):eadi7337. doi: 10.1126/sciadv.adi7337. Epub 2023 Nov 3. PMID: 37922350; PMCID: PMC10624355. 10.1126/sciadv.adi7337. Discussed on Nov. 11, 2024
  • Machado H, Hofer P, Zechner R, Smith TK, Figueiredo LM. Adipocyte lipolysis protects mice against Trypanosoma brucei infection. Nat Microbiol. 2023 Nov;8(11):2020-2032. doi: 10.1038/s41564-023-01496-7. Epub 2023 Oct 12. PMID: 37828246; PMCID: PMC10627827. https://doi.org/10.1038/s41564-023-01496-7. Discussed on Oct. 28, 2024
  • Sonsalla MM, Babygirija R, Johnson M, Cai S, Cole M, Yeh CY, Grunow I, Liu Y, Vertein D, Calubag MF, Trautman ME, Green CL, Rigby MJ, Puglielli L, Lamming DW. Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. Geroscience. 2024 Sep 14. doi: 10.1007/s11357-024-01337-3. Epub ahead of print. PMID: 39271570. 10.1007/s11357-024-01337-3. Discussed on Sept. 30, 2024
  • Bolognini, D., Halgren, A., Lou, R.N. et al. Recurrent evolution and selection shape structural diversity at the amylase locus. Nature (2024). 10.1038/s41586-024-07911-1. Discussed on Sept. 16, 2024
  • Crujeiras AB, Izquierdo AG, Primo D, Milagro FI, Sajoux I, Jácome A, Fernandez-Quintela A, Portillo MP, Martínez JA, Martinez-Olmos MA, de Luis D, Casanueva FF. Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity. Clin Nutr. 2021 Jun;40(6):3959-3972. doi: 10.1016/j.clnu.2021.05.010. Epub 2021 May 21. PMID: 34139469. 10.1016/j.clnu.2021.05.010. Discussed on April 5, 2024
  • Ryan JP, Karim HT, Aizenstein HJ, Helbling NL, Toledo FGS. Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage. 2018 May 1;171:268-276. doi: 10.1016/j.neuroimage.2018.01.024. Epub 2018 Jan 13. PMID: 29339315; PMCID: PMC5857474. 10.1016/j.neuroimage.2018.01.024. Discussed on March 29, 2024
  • Berry A, Collacchi B, Capoccia S, D'Urso MT, Cecchetti S, Raggi C, Sestili P, Aricò E, Pontecorvi G, Puglisi R, Ortona E, Cirulli F. Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer. Front Behav Neurosci. 2021 Jul 9;15:660738. doi: 10.3389/fnbeh.2021.660738. PMID: 34305544; PMCID: PMC8298821. 10.3389/fnbeh.2021.660738. Discussed on March 22, 2024
  • Moore MP, Shryack G, Alessi I, Wieschhaus N, Meers GM, Johnson SA, Wheeler AA, Ibdah JA, Parks EJ, Rector RS. Relationship Between Serum ?-Hydroxybutyrate and Hepatic Fatty Acid Oxidation in Individuals with Obesity and NAFLD. Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00336.2023. Epub ahead of print. PMID: 38381399. 10.1152/ajpendo.00336.2023. Discussed on March 15, 2024

Comments on Papers

  • Owen Vaughn, Theresa Powell and Thomas Jansson. Glucocorticoid regulation of amino acid transport in primary human trophoblast cells 2019. Journal of Molecular Endocrinology 63(4):239-248 Full Text Our Thoughts Details.
    • Article has an altmetric score of 3
  • Rachel Perry, Jon Resch, Amelia Douglass, Joseph Madara, Aviva Rabin-Court, Hakan Kucukdereli, Chen Wu, Joongyu Song, Bradford Lowell and Gerald Shulman. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents 2019. Proceedings of the National Academy of Sciences 116(27):13670-13679 Full Text Our Thoughts Details.
    • Article has an altmetric score of 126
  • Vincente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline White, Elizabeth Tuck, Edward Ryder, Diane Gleason, Himsha Beltran, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth Busch-Nentwich, Antonella Galli, James Smith, Elizabeth Robertson, David Adams, Wolfgang Weninger, Timothy Mohun and Myriam Hemberger. Placentation defects are highly prevalent in embryonic lethal mouse mutants 2018. Nature 555(7697):463-468 Full Text Our Thoughts Details.
    • Article has an altmetric score of 155
  • Morten Lyng Hogild, Ann Mosegaard Bak, Steen Bonlokke Pedersen, Jorgen Rungby, Jan Frystyk, Niels Moller, Niels Jessen and Jens Otto Lunde Jorgensen. Growth hormone signaling and action in obese versus lean human subjects 2019. American Journal of Physiology - Endocrinology and Metabolism 316(2):E333-E344 Full Text Our Thoughts Details.
    • Article has an altmetric score of 6
  • Benjamin Hopkins, Chantal Pauli, Xing Du, Diana Wang, Xiang Li, David Wu, Solomon Amadiume, Marcus Goncalves, Cindy Hodakoski, Mark Lundquist, Rohan Bareja, Yan Ma, Emily Harris, Andrea Sboner, Himsha Beltran, Siddhartha Mukherjee and Lewis Cantley. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors 2018. Nature 560(7719):499-503 Full Text Our Thoughts Details.
    • Article has an altmetric score of 1329
  • Meiyuan Zhang, Weilan Sun, Jin Qian and Yan Tang. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid beta-oxidation and ketogenesis via activating XBP1 signaling in liver 2018. Redox Biology 16(February):87-96 Full Text Our Thoughts Details.
    • Article has an altmetric score of 3
  • Graeme Lancaster, Katherine Langley, Nils Anton Berglund, Helene Kammoun, Saskia Reibe, Emma Estevez, Jacquelyn Weir, Natalie Mellett, Gerard Pernes, James Conway, Man Lee, Paul Timpson, Andrew Murphy, Seth Masters, Steve Gerondakis, Nenad Bartonicek, Dominik Kaczorowski, Marcel Dinger, Peter Meikle, Peter Bond and Mark Febbraio. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism 2018. Cell Metabolism Full Text Our Thoughts Details.
    • Article has an altmetric score of 98
  • Choolson Jang, Sheng Hui, Wenyun Lu, Alexis Cowan, Raphael Morscher, Gina Lee, Wei Liu, Gregory Tesz, Morris Birnbaum and Joshua Rabinowitz. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids 2018. Cell Metabolism 27(2):351-361 Full Text Our Thoughts Details.
    • Article has an altmetric score of 1085
  • Naresh Bal, Santosh Maurya, Danesh Sopariwala, Sanjaya Sahoo, Subash Gupta, Sana Shaikh, Meghna Pant, Leslie Rowland, Eric Bombardier, Sanjeewa Goonasekera, Russel Tupling, Jeffery Molkentin and Muthu Periasamy. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. 2012. Nature Medicine 18(19):1575-9 Full Text Our Thoughts Details.
    • Article has an altmetric score of 24
  • Kevin Hall, Thomas Bemis, Robert Brychta, Kong Chen, Amber Courvillle, Emma Crayner, Stephanie Goodwin, Juen Guo, Lillian Howard, Nicolas Knuth, Bernard Miller, Carla Prado, Maria Siervo, Monica Skarulis, Mary Walter, Peter Walter and Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity 2015. Cell Metabolism 22(3):427-436 Full Text Our Thoughts Details.
    • Article has an altmetric score of 1054
  • Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki and Ryozo Nagai. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. 2008. Nature Medicine 14(6):656-666 Full Text Our Thoughts Details.
    • Article has an altmetric score of 2
  • Andrew Shin, Martin Fasshauer, Nika Filatova, Linus Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, Claudia Lindtner, Amanda Lapworth, Olga Ilkayeva, Uwe Knippschild, Anna Wolf, Ludger Shedja, Kevin Grove, Richard Smith, Wei-Jun Qian, Chrisopher Lynch, Christopher Newgard and Christophe Buettner. Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. 2014. Cell metabolism S1550-4131(14):00400-8 Full Text Our Thoughts Details.
    • Article has an altmetric score of 36
  • O. Nelson, Jingxiang Huang, Heiko Jansen, Elizabeth Galbreath, Kurt Morgenstern, Jamie Gehring, Kimberly Rigano, Jae Lee, Jianhua Gong, Adam Shaywitz, Chantal Vella, Charles Robbins and Kevin Corbit. Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation 2014. Cell Metabolism 20(2):376-82 Full Text Our Thoughts Details.
    • Article has an altmetric score of 225
  • Robert Koza, Larissa Nikonova, Jessica Hogan, Jong-Seop Rim, Tamra Mendoza, Christopher Faulk, Jihad Skaf and Leslie Kozak. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. 2006. PLOS Genetics 2(5):e81 Full Text Our Thoughts Details.
    • Article has an altmetric score of 16
  • Xiaoyuan Xu, Ambar Grijalva, Alicja Skowronski, Marco van Eijk, Mireille J Serlie and Anthony Ferrante. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. 2014. Cell metabolism 18(6):816-30 Full Text Our Thoughts Details.
    • Article has an altmetric score of 12
  • Hui Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel Squillace, Chin-Lee Wu and Brendan Manning. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. 2009. PLOS One 4(7):e6189 Full Text Our Thoughts Details.
    • Article has an altmetric score of 6
  • Alexander von Wilamowitz-Moellendorff, Roger Hunter, Mar Garcia-Rocha, Li Kang, Iliana Lopez-Soldado, Louise Lantier, Kashyap Patel, Mark Peggie, Carlos Martinez-Pons, Martin Voss, Joaquim Calbo, Patricia Cohen, David Wasserman, Joan Guinovart and Kei Sakamoto. Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. 2013. Diabetes Full Text Our Thoughts Details.
    • Article has an altmetric score of 2
  • Christine Longuet, Elaine Sinclair, Adriano Maida, Laurie Baggio, Marlena Maziarz, Maureen Charron and Daniel Drucker. The glucagon receptor is required for the adaptive metabolic response to fasting. 2008. Cell Metabolism 8(5):359-71 Full Text Our Thoughts Details.
    • Article has an altmetric score of 10
  • Subhash Katewa, Fabio Demontis, Marysia Kolipinski, Alan Hubbard, Matthew Gill, Norbert Perrimon, Simon Melov and Pankaj Kapahi. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. 2012. Cell metabolism 16(1):97-103 Full Text Our Thoughts Details.
    • Article has an altmetric score of 2
  • Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Akihiro Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi and Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. 2013. Proceedings of the National Academy of Sciences of the United States of America 110(5):1726-31 Full Text Our Thoughts Details.
    • Article has an altmetric score of 5