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The glucagon receptor is required for the adaptive metabolic response to fasting.

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This paper characterizes the effects of the loss of the glucagaon receptor on lipid homeostasis. Using a combination of live animal and tissue culture experiments, they identify reduced fasting lipid oxidation and triglyceride mobilization in these mice. The authors propose that this increase in lipid oxidation causes reduced lipogenesis as well. They further characterize the mechanism of glucagon mediated lipid oxidation to require PPARa These findings are consistent with the key role of glucagon in the mobilization of fat in fasting conditions. The role of glucagon resistance in the development of steatosis has been an underexplored area and this paper provides key insights into glucagon dependent changes in fasting lipid levels.

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