Journal Club Articles

November 2024 Journal Club Articles

Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J, Li F, Xiong W, Rao S, Xiang Q, Shi W, Song T, Deng J, Yin Y, Tan C. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci Adv. 2023 Nov 3;9(44):eadi7337. doi: 10.1126/sciadv.adi7337. Epub 2023 Nov 3. PMID: 37922350; PMCID: PMC10624355. 10.1126/sciadv.adi7337. Discussed on Nov. 11, 2024

October 2024 Journal Club Articles

Machado H, Hofer P, Zechner R, Smith TK, Figueiredo LM. Adipocyte lipolysis protects mice against Trypanosoma brucei infection. Nat Microbiol. 2023 Nov;8(11):2020-2032. doi: 10.1038/s41564-023-01496-7. Epub 2023 Oct 12. PMID: 37828246; PMCID: PMC10627827. https://doi.org/10.1038/s41564-023-01496-7. Discussed on Oct. 28, 2024

September 2024 Journal Club Articles

Sonsalla MM, Babygirija R, Johnson M, Cai S, Cole M, Yeh CY, Grunow I, Liu Y, Vertein D, Calubag MF, Trautman ME, Green CL, Rigby MJ, Puglielli L, Lamming DW. Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. Geroscience. 2024 Sep 14. doi: 10.1007/s11357-024-01337-3. Epub ahead of print. PMID: 39271570. 10.1007/s11357-024-01337-3. Discussed on Sept. 30, 2024

Bolognini, D., Halgren, A., Lou, R.N. et al. Recurrent evolution and selection shape structural diversity at the amylase locus. Nature (2024). 10.1038/s41586-024-07911-1. Discussed on Sept. 16, 2024

April 2024 Journal Club Articles

Crujeiras AB, Izquierdo AG, Primo D, Milagro FI, Sajoux I, Jácome A, Fernandez-Quintela A, Portillo MP, Martínez JA, Martinez-Olmos MA, de Luis D, Casanueva FF. Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity. Clin Nutr. 2021 Jun;40(6):3959-3972. doi: 10.1016/j.clnu.2021.05.010. Epub 2021 May 21. PMID: 34139469. 10.1016/j.clnu.2021.05.010. Discussed on April 5, 2024

March 2024 Journal Club Articles

Ryan JP, Karim HT, Aizenstein HJ, Helbling NL, Toledo FGS. Insulin sensitivity predicts brain network connectivity following a meal. Neuroimage. 2018 May 1;171:268-276. doi: 10.1016/j.neuroimage.2018.01.024. Epub 2018 Jan 13. PMID: 29339315; PMCID: PMC5857474. 10.1016/j.neuroimage.2018.01.024. Discussed on March 29, 2024

Berry A, Collacchi B, Capoccia S, D'Urso MT, Cecchetti S, Raggi C, Sestili P, Aricò E, Pontecorvi G, Puglisi R, Ortona E, Cirulli F. Chronic Isolation Stress Affects Central Neuroendocrine Signaling Leading to a Metabolically Active Microenvironment in a Mouse Model of Breast Cancer. Front Behav Neurosci. 2021 Jul 9;15:660738. doi: 10.3389/fnbeh.2021.660738. PMID: 34305544; PMCID: PMC8298821. 10.3389/fnbeh.2021.660738. Discussed on March 22, 2024

Moore MP, Shryack G, Alessi I, Wieschhaus N, Meers GM, Johnson SA, Wheeler AA, Ibdah JA, Parks EJ, Rector RS. Relationship Between Serum ?-Hydroxybutyrate and Hepatic Fatty Acid Oxidation in Individuals with Obesity and NAFLD. Am J Physiol Endocrinol Metab. 2024 Feb 21. doi: 10.1152/ajpendo.00336.2023. Epub ahead of print. PMID: 38381399. 10.1152/ajpendo.00336.2023. Discussed on March 15, 2024

February 2024 Journal Club Articles

Lu JF, Zhu MQ, Xia B, Zhang NN, Liu XP, Liu H, Zhang RX, Xiao JY, Yang H, Zhang YQ, Li XM, Wu JW. GDF15 is a major determinant of ketogenic diet-induced weight loss. Cell Metab. 2023 Dec 5;35(12):2165-2182.e7. doi: 10.1016/j.cmet.2023.11.003. Erratum in: Cell Metab. 2024 Feb 6;36(2):454-456. PMID: 38056430. 10.1016/j.cmet.2023.11.003. Discussed on Feb. 23, 2024

Price TR, Emfinger CH, Schueler KL, King S, Nicholson R, Beck T, Yandell BS, Summers SA, Holland WL, Krauss RM, Keller MP, Attie AD. Identification of genetic drivers of plasma lipoprotein size in the Diversity Outbred mouse population. J Lipid Res. 2023 Dec;64(12):100471. doi: 10.1016/j.jlr.2023.100471. Epub 2023 Nov 7. PMID: 37944753; PMCID: PMC10750189. 10.1016/j.jlr.2023.100471. Discussed on Feb. 16, 2024

Trommelen J, van Lieshout GAA, Nyakayiru J, Holwerda AM, Smeets JSJ, Hendriks FK, van Kranenburg JMX, Zorenc AH, Senden JM, Goessens JPB, Gijsen AP, van Loon LJC. The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans. Cell Rep Med. 2023 Dec 19;4(12):101324. doi: 10.1016/j.xcrm.2023.101324. PMID: 38118410; PMCID: PMC10772463. 10.1016/j.xcrm.2023.101324. Discussed on Feb. 9, 2024

McClean PL, Hölscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology. 2014 Jan;76 Pt A:57-67. doi: 10.1016/j.neuropharm.2013.08.005. Epub 2013 Aug 21. PMID: 23973293. 10.1016/j.neuropharm.2013.08.005. Discussed on Feb. 2, 2024

January 2024 Journal Club Articles

Soták M, Casselbrant A, Rath E, Zietek T, Strömstedt M, Adingupu DD, Karlsson D, Fritsch Fredin M, Ergang P, Pácha J, Batorsky A, Alpers CE, Börgeson E, Hansen PBL, Ericsson A, Björnson Granqvist A, Wallenius V, Fändriks L, Unwin RJ. Intestinal sodium/glucose cotransporter 3 expression is epithelial and downregulated in obesity. Life Sci. 2021 Feb 15;267:118974. doi: 10.1016/j.lfs.2020.118974. Epub 2020 Dec 30. PMID: 33385407. 10.1016/j.lfs.2020.118974. Discussed on Jan. 26, 2024

O'Donnell MG, Stumpp L, Gallaher MJ, Powers RW. Pre-pregnancy stress induces maternal vascular dysfunction during pregnancy and postpartum. Reprod Sci. 2023 Nov;30(11):3197-3211. doi: 10.1007/s43032-023-01248-2. Epub 2023 May 23. PMID: 37219786; PMCID: PMC10204668. 10.1007/s43032-023-01248-2. Discussed on Jan. 19, 2024

December 2023 Journal Club Articles

Mey JT, Vandagmansar B, Dantas WS, Belmont KP, Axelrod CL, Kirwan JP. Ketogenic propensity is differentially related to lipid-induced hepatic and peripheral insulin resistance. Acta Physiol (Oxf). 2023 Dec;239(4):e14054. doi: 10.1111/apha.14054. Epub 2023 Oct 16. PMID: 37840478. 10.1111/apha.14054. Discussed on Dec. 1, 2023

November 2023 Journal Club Articles

Gupta DK, Lewis CE, Varady KA, Su YR, Madhur MS, Lackland DT, Reis JP, Wang TJ, Lloyd-Jones DM, Allen NB. Effect of Dietary Sodium on Blood Pressure: A Crossover Trial. JAMA. 2023 Nov 11:e2323651. doi: 10.1001/jama.2023.23651. Epub ahead of print. PMID: 37950918; PMCID: PMC10640704. 10.1001/jama.2023.23651. Discussed on Nov. 24, 2023

Wang KC, Woung LC, Tsai MT, Liu CC, Su YH, Li CY. Risk of Alzheimer's disease in relation to diabetes: a population-based cohort study. Neuroepidemiology. 2012;38(4):237-44. doi: 10.1159/000337428. Epub 2012 May 5. PMID: 22572745. 10.1159/000337428.. Discussed on Nov. 10, 2023

Murray AJ, Knight NS, Cochlin LE, McAleese S, Deacon RM, Rawlins JN, Clarke K. Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J. 2009 Dec;23(12):4353-60. doi: 10.1096/fj.09-139691. Epub 2009 Aug 10. PMID: 19667117. 10.1096/fj.09-139691. Discussed on Nov. 3, 2023

October 2023 Journal Club Articles

Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. Lancet. 2017 Feb 25;389(10071):834-845. doi: 10.1016/S0140-6736(16)31714-7. Epub 2017 Jan 12. Erratum in: Lancet. 2017 Feb 25;389(10071):804. Erratum in: Lancet. 2017 Feb 25;389(10071):804. PMID: 28088338; PMCID: PMC7864285. 10.1016/S0140-6736(16)31714-7.. Discussed on Oct. 20, 2023

Norwitz NG, Feldman D, Soto-Mota A, Kalayjian T, Ludwig DS. Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a "Lean Mass Hyper-Responder" Phenotype. Curr Dev Nutr. 2021 Nov 30;6(1):nzab144. doi: 10.1093/cdn/nzab144. PMID: 35106434; PMCID: PMC8796252. 10.1093/cdn/nzab144. Discussed on Oct. 13, 2023

September 2023 Journal Club Articles

Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, Wang H, McHugh N, Bramato B, Morrision B, Rothstein JD, Khvorova A, Czech MP. Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis. bioRxiv [Preprint]. 2023 Oct 19:2023.05.03.539244. doi: 10.1101/2023.05.03.539244. PMID: 37205462; PMCID: PMC10187148. 10.1101/2023.05.03.539244. Discussed on Sept. 29, 2023

Wolters FJ, Chibnik LB, Waziry R, Anderson R, Berr C, Beiser A, Bis JC, Blacker D, Bos D, Brayne C, Dartigues JF, Darweesh SKL, Davis-Plourde KL, de Wolf F, Debette S, Dufouil C, Fornage M, Goudsmit J, Grasset L, Gudnason V, Hadjichrysanthou C, Helmer C, Ikram MA, Ikram MK, Joas E, Kern S, Kuller LH, Launer L, Lopez OL, Matthews FE, McRae-McKee K, Meirelles O, Mosley TH Jr, Pase MP, Psaty BM, Satizabal CL, Seshadri S, Skoog I, Stephan BCM, Wetterberg H, Wong MM, Zettergren A, Hofman A. Twenty-seven-year time trends in dementia incidence in Europe and the United States: The Alzheimer Cohorts Consortium. Neurology. 2020 Aug 4;95(5):e519-e531. doi: 10.1212/WNL.0000000000010022. Epub 2020 Jul 1. PMID: 32611641; PMCID: PMC7455342. 10.1212/WNL.0000000000010022. Discussed on Sept. 22, 2023

Abi-Ghanem C, Salinero AE, Kordit D, Mansour FM, Kelly RD, Venkataganesh H, Kyaw NR, Gannon OJ, Riccio D, Fredman G, Poitelon Y, Belin S, Kopec AM, Robison LS, Zuloaga KL. Sex differences in the effects of high fat diet on underlying neuropathology in a mouse model of VCID. Biol Sex Differ. 2023 May 19;14(1):31. doi: 10.1186/s13293-023-00513-y. PMID: 37208759; PMCID: PMC10199629. 10.1186/s13293-023-00513-y. Discussed on Sept. 15, 2023

Chiba T, Takaguri A, Kooka A, Kowatari K, Yoshizawa M, Fukushi Y, Hongo F, Sato H, Fujisawa M, Wada S, Maeda T. Suppression of milk-derived miR-148a caused by stress plays a role in the decrease in intestinal ZO-1 expression in infants. Clin Nutr. 2022 Dec;41(12):2691-2698. doi: 10.1016/j.clnu.2022.10.004. Epub 2022 Oct 13. PMID: 36343560. 10.1016/j.clnu.2022.10.004. Discussed on Sept. 8, 2023

Miyamoto J, Ohue-Kitano R, Mukouyama H, Nishida A, Watanabe K, Igarashi M, Irie J, Tsujimoto G, Satoh-Asahara N, Itoh H, Kimura I. Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23813-23821. 10.1073/pnas.1912573116. Discussed on Sept. 1, 2023

August 2023 Journal Club Articles

Linden MA, Burke SJ, Pirzadah HA, Huang TY, Batdorf HM, Mohammed WK, Jones KA, Ghosh S, Campagna SR, Collier JJ, Noland RC. Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration. Mol Metab. 2023 Aug;74:101751. 10.1016/j.molmet.2023.101751. Discussed on Aug. 25, 2023

March 2023 Journal Club Articles

Fu X, Fletcher JA, Deja S, Inigo-Vollmer M, Burgess SC, Browning JD. Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver. J Clin Invest. 2023 May 1;133(9):e167442 10.1172/JCI167442. Discussed on March 23, 2023

June 2022 Journal Club Articles

Shannon, C. E., Merovci, A., Fourcaudot, M., Tripathy, D., Abdul-Ghani, M., Wang, H., Han, X., Norton, L., and DeFronzo, R. A. (2022) Effects of Sustained Hyperglycemia on Skeletal Muscle Lipids in Healthy Subjects. J. Clin. Endocrinol. Metab. In Press, 1–10 10.1210/clinem/dgac306. Discussed on June 10, 2022

Kalafut, K. C., Mitchell, S. J., MacArthur, M. R., and Mitchell, J. R. (2022) Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction. Front. Nutr. 9, 1–12 10.3389/fnut.2022.839341. Discussed on June 3, 2022

May 2022 Journal Club Articles

Dukay-Szabó, S., Simon, D., Varga, M., Koller, O., Pataki, Z., Rigó, J., and Túry, F. (2022) The applicability of the Eating Disorder Inventory in pregnancy. Eat. Weight Disord. 27, 629–637 10.1007/s40519-021-01197-2. Discussed on May 6, 2022

April 2022 Journal Club Articles

Díaz, M., Campderrós, L., Guimaraes, M. P., López-Bermejo, A., de Zegher, F., Villarroya, F., and Ibáñez, L. (2020) Circulating growth-and-differentiation factor-15 in early life: relation to prenatal and postnatal growth and adiposity measurements. Pediatr. Res. 87, 897–902 10.1038/s41390-019-0633-z. Discussed on April 15, 2022

Solmonson, A., Faubert, B., Gu, W., Rao, A., Cowdin, M. A., Menendez-Montes, I., Kelekar, S., Rogers, T. J., Pan, C., Guevara, G., Tarangelo, A., Zacharias, L. G., Martin-Sandoval, M. S., Do, D., Pachnis, P., Dumesnil, D., Mathews, T. P., Tasdogan, A., Pham, A., Cai, L., Zhao, Z., Ni, M., Cleaver, O., Sadek, H. A., Morrison, S. J., and DeBerardinis, R. J. (2022) Compartmentalized metabolism supports midgestation mammalian development. Nature. 604, 349–353 10.1038/s41586-022-04557-9. Discussed on April 8, 2022

Edwards, M. A., Muraleedharan, D., and Spaulding, A. (2022) Racial disparities in reasons for mortality following bariatric surgery. J. Racial Ethn. Heal. Disparities. 10.1007/s40615-022-01242-5 10.1007/s40615-022-01242-5. Discussed on April 1, 2022

March 2022 Journal Club Articles

Sharma, A. J., Bulkley, J. E., Stoneburner, A. B., Dandamudi, P., Leo, M., Callaghan, W. M., and Vesco, K. K. (2021) Bias in Self-reported Prepregnancy Weight Across Maternal and Clinical Characteristics. Matern. Child Health J. 25, 1242–1253 10.1007/s10995-021-03149-9. Discussed on March 25, 2022

Chaix, A., Deota, S., Bhardwaj, R., Lin, T., and Panda, S. (2021) Sex- and age-dependent outcomes of 9-hour time-restricted feeding of a Western high-fat high-sucrose diet in C57BL/6J mice. Cell Rep. 36, 109543 10.1016/j.celrep.2021.109543. Discussed on March 18, 2022

May 2020 Journal Club Articles

Plessow F, Singhal V, Toth AT, Micali N, Eddy KT, Misra M. Estrogen administration improves the trajectory of eating disorder pathology in oligo-amenorrheic athletes: A randomized controlled trial. Psychoneuroendocrinology 102: 273–280, 2019. 10.1016/j.psyneuen.2018.11.013. Discussed on May 15, 2020

Keleher MR, Erickson K, Kechris K, Yang I V., Dabelea D, Friedman JE, Boyle KE, Jansson T. Associations between the activity of placental nutrient-sensing pathways and neonatal and postnatal metabolic health: the ECHO Healthy Start cohort. Int. J. Obes. (2020). 10.1038/s41366-020-0574-y. Discussed on May 15, 2020

Hall KD, Guo J, Courville AB, Boring J, Brychta R, Kong Y, Darcey V, Forde CG, Gharib AM, Gallagher I, Howard R, Joseph P V, Milley L, Ouwerkerk R, Rozga I, Schick A, Stagliano M, Torres S, Chung ST. A plant-based, low-fat diet decreases ad libitum energy intake compared to an animal-based, ketogenic diet: An inpatient randomized controlled trial. NutRxiv (2020). doi: 10.31232/osf.io/rdjfb. 10.31232/osf.io/rdjfb. Discussed on May 15, 2020

Meddens SFW, de Vlaming R, Bowers P, Burik CAP, Linnér RK, Lee C, Okbay A, Turley P, Rietveld CA, Fontana MA, Ghanbari M, Imamura F, McMahon G, van der Most PJ, Voortman T, Wade KH, Anderson EL, Braun KVE, Emmett PM, Esko T, Gonzalez JR, Kiefte-de Jong JC, Langenberg C, Luan J, Muka T, Ring S, Rivadeneira F, Snieder H, van Rooij FJA, Wolffenbuttel BHR, Smith GD, Franco OH, Forouhi NG, Ikram MA, Uitterlinden AG, van Vliet-Ostaptchouk J V., Wareham NJ, Cesarini D, Harden KP, Lee JJ, Benjamin DJ, Chow CC, Koellinger PD. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle. Mol. Psychiatry ( May 11, 2020). doi: 10.1038/s41380-020-0697-5. 10.1038/s41380-020-0697-5. Discussed on May 15, 2020

Orr SK, Dachner N, Frank L, Tarasuk V. Relation between household food insecurity and breastfeeding in Canada. Cmaj 190: E312–E319, 2018. 10.1503/cmaj.170880. Discussed on May 8, 2020

Strahm AM, Bagne AG, Rued HA, Larson KJ, Roemmich JN, Hilmert CJ. Prenatal traumatic stress and offspring hair cortisol concentration: A nine year follow up to the Red River flood pregnancy study. Psychoneuroendocrinology 113: 104579, 2020. 10.1016/j.psyneuen.2019.104579. Discussed on May 8, 2020

Tverdal A, Selmer R, Cohen JM, Thelle DS. Coffee consumption and mortality from cardiovascular diseases and total mortality: Does the brewing method matter? Eur. J. Prev. Cardiol. (2020). doi: 10.1177/2047487320914443. 10.1177/2047487320914443. Discussed on May 8, 2020

Norrelund H, Nair KS, Jorgensen JOL, Christiansen JS, Moller N. The Protein-Retaining Effects of Growth Hormone During Fasting Involve Inhibition of Muscle-Protein Breakdown. Diabetes 50: 96–104, 2001. 10.2337/diabetes.50.1.96. Discussed on May 8, 2020

Roumans KHM, Lindeboom L, Veeraiah P, Remie CME, Phielix E, Havekes B, Bruls YMH, Brouwers MCGJ, Ståhlman M, Alssema M, Peters HPF, de Mutsert R, Staels B, Taskinen MR, Borén J, Schrauwen P, Schrauwen-Hinderling VB. Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance. Nat Commun 11: 1–11, 2020. 10.1038/s41467-020-15684-0. Discussed on May 1, 2020

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JTJ, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O’Rahilly S. GDF15 mediates the effects of metformin on body weight and energy balance. Nature 578: 444–448, 2020. 10.1038/s41586-019-1911-y. Discussed on May 1, 2020

Chowdhury EA, Richardson JD, Tsintzas K, Thompson D, Betts JA. Carbohydrate-rich breakfast attenuates glycaemic, insulinaemic and ghrelin response to ad libitum lunch relative to morning fasting in lean adults. Br J Nutr 114: 98–107, 2015. 10.1017/S0007114515001506. Discussed on May 1, 2020

Murphy C, Koehler K. Caloric restriction induces anabolic resistance to resistance exercise. Eur J Appl Physiol 120: 1155–1164, 2020. 10.1007/s00421-020-04354-0. Discussed on May 1, 2020

April 2020 Journal Club Articles

Stratton MT, Tinsley GM, Alesi MG, Hester GM, Olmos AA, Serafini PR, Modjeski AS, Mangine GT, King K, Savage SN, Webb AT, VanDusseldorp TA. Four Weeks of Time-Restricted Feeding Combined with Resistance Training Does Not Differentially Influence Measures of Body Composition, Muscle Performance, Resting Energy Expenditure, and Blood Biomarkers. Nutrients 12: 1126, 2020. 10.3390/nu12041126. Discussed on April 24, 2020

O’Brien KM, Tronick EZ, Moore CL. Relationship between hair cortisol and perceived chronic stress in a diverse sample. Stress Heal 29: 337–344, 2013. 10.1002/smi.2475. Discussed on April 24, 2020

Lau C, Hurst NM, Smith EO, Schanler RJ. Ethnic/racial diversity, maternal stress, lactation and very low birthweight infants. J Perinatol 27: 399–408, 2007. 10.1038/sj.jp.7211770. Discussed on April 24, 2020

Raymond J, Morin A, Plamondon H. Delivery method matters: omega-3 supplementation by restricted feeding period and oral gavage has a distinct impact on corticosterone secretion and anxious behavior in adolescent rats. Nutr Neurosci 0: 1–11, 2020. 10.1080/1028415X.2020.1733813. Discussed on April 24, 2020

Schnurr TM, Jakupovi H, Carrasquilla GD, Ängquist L, Grarup N, Sørensen TIA, Tjønneland A, Overvad K, Pedersen O, Hansen T, Kilpeläinen TO. Obesity, unfavourable lifestyle and genetic risk of type 2 diabetes: a case-cohort study. Diabetologia ( April 15, 2020). 10.1007/s00125-020-05140-5. Discussed on April 17, 2020

Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: Relevance of glucocorticoid signaling. Genome Biol 16: 1–12, 2015. 10.1186/s13059-015-0828-5. Discussed on April 17, 2020

Otsuka H, Kimura T, Ago Y, Nakama M, Aoyama Y, Abdelkreem E, Matsumoto H, Ohnishi H, Sasai H, Osawa M, Yamaguchi S, Mitchell GA, Fukao T. Deficiency of 3-hydroxybutyrate dehydrogenase (BDH1) in mice causes low ketone body levels and fatty liver during fasting. J Inherit Metab Dis 1: 2–31, 2020. 10.1002/jimd.12243. Discussed on April 17, 2020

Higgins KA, Considine R V., Mattes RD. Aspartame consumption for 12 weeks does not affect glycemia, appetite, or body weight of healthy, lean adults in a randomized controlled trial. J Nutr 148: 650–657, 2018. 10.1093/jn/nxy021. Discussed on April 3, 2020

Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF. The proximal origin of SARS-CoV-2. Nat Med 89: 44–48, 2020. 10.1038/s41591-020-0820-9. Discussed on April 3, 2020

Markova M, Koelman L, Hornemann S, Pivovarova O, Sucher S, Machann J, Rudovich N, Thomann R, Schneeweiss R, Rohn S, Pfeiffer AFH, Aleksandrova K. Effects of plant and animal high protein diets on immune-inflammatory biomarkers: A 6-week intervention trial. Clin Nutr 39: 862–869, 2020. 10.1016/j.clnu.2019.03.019. Discussed on April 3, 2020

Sugawara J, Iwama N, Hoshiai T, Tokunaga H, Nishigori H, Metoki H, Okamura K, Yaegashi N. Regional Birth Outcomes after the 2011 Great East Japan Earthquake and Tsunami in Miyagi Prefecture. Prehosp Disaster Med : 1–5, 2018. 10.1017/S1049023X18000183. Discussed on April 3, 2020

March 2020 Journal Club Articles

Badman MK, Kennedy AR, Adams ACC, Pissios P, Maratos-flier E. A very low carbohydrate ketogenic diet improves glucose tolerance in ob/ob mice independently of weight loss. Am J Physiol - Endocrinol Metab 297: 1197–1204, 2009. 10.1152/ajpendo.00357.2009. Discussed on March 27, 2020

Heikura IA, Burke LM, Hawley JA, Ross ML, Garvican-Lewis L, Sharma AP, McKay AKA, Leckey JJ, Welvaert M, McCall L, Ackerman KE. A Short-Term Ketogenic Diet Impairs Markers of Bone Health in Response to Exercise. Front Endocrinol (Lausanne) 10: 1–10, 2020. 10.3389/fendo.2019.00880. Discussed on March 27, 2020

Nakayasu ES, Syed F, Tersey SA, Gritsenko MA, Mitchell HD, Chan CY, Dirice E, Turatsinze JV, Cui Y, Kulkarni RN, Eizirik DL, Qian WJ, Webb-Robertson BJM, Evans-Molina C, Mirmira. RG, Metz TO. Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention. Cell Metab 31: 363-374.e6, 2020. 10.1016/j.cmet.2019.12.005. Discussed on March 27, 2020

Lagström H, Rautava S, Ollila H, Kaljonen A, Turta O, Mäkelä J, Yonemitsu C, Gupta J, Bode L. Associations between human milk oligosaccharides and growth in infancy and early childhood. Am. J. Clin. Nutr. (2020). 10.1093/ajcn/nqaa010. Discussed on March 20, 2020

Bedford JR, Ivermee CL, Lange K, Chapman MJ. Nutrition and functional outcomes after critical illness due to pandemic (H1N1) 2009 influenza: A retrospective cohort study. Crit Care Resusc 13: 226–231, 2011. None. Discussed on March 20, 2020

Upadhyay A, Sinha RA, Kumar A, Godbole MM. Time-restricted feeding ameliorates maternal high-fat diet-induced fetal lung injury. Exp Mol Pathol 114: 104413, 2020. 10.1016/j.yexmp.2020.104413. Discussed on March 20, 2020

Orozco LD, Bennett BJ, Farber CR, Ghazalpour A, Pan C, Che N, Wen P, Qi HX, Mutukulu A, Siemers N, Neuhaus I, Yordanova R, Gargalovic P, Pellegrini M, Kirchgessner T, Lusis AJ. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 151: 658–670, 2012. 10.1016/j.cell.2012.08.043. Discussed on March 13, 2020

Ramsay DT, Kent JC, Hartmann RA, Hartmann PE. Anatomy of the lactating human breast redefined with ultrasound imaging. J Anat 206: 525–534, 2005. 10.1111/j.1469-7580.2005.00417.x. Discussed on March 13, 2020

Richter J, Herzog N, Janka S, Baumann T, Kistenmacher A, Oltmanns KM. Twice as High Diet-Induced Thermogenesis After Breakfast vs Dinner On High-Calorie as Well as Low-Calorie Meals. J Clin Endocrinol Metab 105: 1–11, 2020. 10.1210/clinem/dgz311. Discussed on March 13, 2020

February 2020 Journal Club Articles

McCleary-Gaddy AT, Miller CT, Grover KW, Hodge JJ, Major B. Weight Stigma and Hypothalamic-Pituitary-Adrenocortical Axis Reactivity in Individuals Who Are Overweight. Ann Behav Med 53: 392–398, 2019. 10.1093/abm/kay042. Discussed on Feb. 14, 2020

Hollenbach JP, Kuo CL, Mu J, Gerrard M, Gherlone N, Sylvester F, Ojukwu M, Cloutier MM. Hair cortisol, perceived stress, and social support in mother–child dyads living in an urban neighborhood. Stress 22: 632–639, 2019. 10.1080/10253890.2019.1604667. Discussed on Feb. 14, 2020

Curtis PJ, Van Der Velpen V, Berends L, Jennings A, Feelisch M, Umpleby AM, Evans M, Fernandez BO, Meiss MS, Minnion M, Potter J, Minihane AM, Kay CD, Rimm EB, Cassidy A. Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. Am J Clin Nutr 109: 1535–1545, 2019. 10.1093/ajcn/nqy380. Discussed on Feb. 14, 2020

Liko D, Rzepiela A, Vukojevic V, Zavolan M, Hall MN. Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs . Proc. Natl. Acad. Sci. (2020). 10.1073/pnas.1918931117. Discussed on Feb. 7, 2020

Timmers S, De Vogel-Van Den Bosch J, De Wit N, Schaart G, Van Beurden D, Hesselink M, Van Der Meer R, Schrauwen P. Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice. Nutr Diabetes 1: e11-9, 2011. 10.1038/nutd.2011.7. Discussed on Feb. 7, 2020

Natividade da Silva F, Brunetta HS, Bruxel MA, Gomes FA, Rafacho A. Impact of glucocorticoid treatment before pregnancy on glucose homeostasis of offspring exposed to glucocorticoid in adult life. Life Sci 237: 116913, 2019. 10.1016/j.lfs.2019.116913. Discussed on Feb. 7, 2020

Epel ES, Hartman A, Jacobs LM, Leung C, Cohn MA, Jensen L, Ishkanian L, Wojcicki J, Mason AE, Lustig RH, Stanhope KL, Schmidt LA. Association of a Workplace Sales Ban on Sugar-Sweetened Beverages with Employee Consumption of Sugar-Sweetened Beverages and Health. JAMA Intern Med 180: 9–16, 2020. 10.1001/jamainternmed.2019.4434. Discussed on Feb. 7, 2020

January 2020 Journal Club Articles

Adamovich Y, Rousso-Noori L, Zwighaft Z, Neufeld-Cohen A, Golik M, Kraut-Cohen J, Wang M, Han X, Asher G. Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab 19: 319–330, 2014. 10.1016/j.cmet.2013.12.016. Discussed on Jan. 31, 2020

Gilbertson HR, Brand-Miller JC, Thorburn AW, Evans S, Chondros P, Werther GA. The Effect of Flexible Low Glycemic Index Dietary Advice Versus Measured Carbohydrate Exchange Diets on Glycemic Control in Children With Type 1 Diabetes. Diabetes Care 24: 1137–1143, 2001. 10.2337/diacare.24.7.1137. Discussed on Jan. 31, 2020

D’Anna-Hernandez KL, Ross RG, Natvig CL, Laudenslager ML. Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: Comparison to salivary cortisol. Physiol Behav 104: 348–353, 2011. 10.1016/j.physbeh.2011.02.041. Discussed on Jan. 31, 2020

Gil CI, Ost M, Kasch J, Schumann S, Heider S, Klaus S. Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice. Sci Rep 9: 20120, 2019. 10.1038/s41598-019-56922-w. Discussed on Jan. 17, 2020

Shen MC, Zhao X, Siegal GP, Desmond R, Hardy RW. Dietary stearic acid leads to a reduction of visceral adipose tissue in athymic nude mice. PLoS One 9: 1–12, 2014. 10.1371/journal.pone.0104083. Discussed on Jan. 17, 2020

Grinman DY, Careaga VP, Wellberg EA, Dansey M V., Kordon EC, Anderson SM, Maier MS, Burton G, Maclean PS, Rudolph MC, Pecci A. Liver X receptor-? activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol - Endocrinol Metab 316: E1136–E1145, 2019. 10.1152/ajpendo.00548.2018. Discussed on Jan. 17, 2020

Denisova EI, Kozhevnikova V V, Bazhan NM, Makarova EN. Sex?specific effects of leptin administration to pregnant mice on the placentae and the metabolic phenotypes of offspring. FEBS Open Bio 10: 96–106, 2020. 10.1002/2211-5463.12757. Discussed on Jan. 17, 2020

Miller AC, Polgreen LA, Segre EM, Polgreen PM. Variations in Marginal Taste Perception by Body Mass Index Classification: A Randomized Controlled Trial. J Acad Nutr Diet 120: 45–52, 2019. 10.1016/j.jand.2019.05.018. Discussed on Jan. 17, 2020

November 2019 Journal Club Articles

Daly M, Sutin AR, Robinson E. Perceived Weight Discrimination Mediates the Prospective Association Between Obesity and Physiological Dysregulation: Evidence From a Population-Based Cohort. Psychol. Sci. (2019). 10.1177/0956797619849440. Discussed on Nov. 1, 2019

October 2019 Journal Club Articles

Michael Anson R, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK, Lane MA, Mattson MP. Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake. Proc Natl Acad Sci U S A 100: 6216–6220, 2003. 10.1073/pnas.1035720100. Discussed on Oct. 25, 2019

Alexander N, Illius S, Stalder T, Wankerl M, Muehlhan M, Kirschbaum C. Serotonin transporter gene methylation predicts long-term cortisol concentrations in hair. Psychoneuroendocrinology 106: 179–182, 2019. 10.1016/j.psyneuen.2019.03.033. Discussed on Oct. 25, 2019

Volek JS, Freidenreich DJ, Saenz C, Kunces LJ, Creighton BC, Bartley JM, Davitt PM, Munoz CX, Anderson JM, Maresh CM, Lee EC, Schuenke MD, Aerni G, Kraemer WJ, Phinney SD. Metabolic characteristics of keto-adapted ultra-endurance runners. Metabolism 65: 100–110, 2016. 10.1016/j.metabol.2015.10.028. Discussed on Oct. 25, 2019

Castillo-Castrejon M, Jansson T, Powell TL. No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in obesity and gestational diabetes mellitus. Am. J. Physiol. Metab. (2019). 10.1152/ajpendo.00196.2019. Discussed on Oct. 18, 2019

Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, Zhao X, Li N, Li S, Xue G, Cheng W, Li B, Li H, Lin W, Tian C, Zhao J, Han J, An D, Zhang Q, Wei H, Zheng M, Ma X, Li W, Chen X, Zhang Z, Zeng H, Ying S, Wu J, Yang R, Liu D. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metab 30: 675-688.e7, 2019. 10.1016/j.cmet.2019.08.018. Discussed on Oct. 18, 2019

Henkel J, Alfine E, Saín J, Jöhrens K, Weber D, Castro JP, König J, Stuhlmann C, Vahrenbrink M, Jonas W, Kleinridders A, Püschel GP. Soybean oil-derived poly-unsaturated fatty acids enhance liver damage in NAFLD induced by dietary cholesterol. Nutrients 10, 2018. 10.3390/nu10091326. Discussed on Oct. 18, 2019

Neacsu M, Fyfe C, Horgan G, Johnstone AM. Appetite control and biomarkers of satiety with Vegetarian (soy) and meat-based high-protein diets for weight loss in obese men: A randomized crossover trial. Am J Clin Nutr 100: 548–558, 2014. 10.3945/ajcn.113.077503. Discussed on Oct. 18, 2019

September 2019 Journal Club Articles

Boucsein A, Rizwan MZ, Tups A. Hypothalamic leptin sensitivity and health benefits of time-restricted feeding are dependent on the time of day in male mice. FASEB J 3: fj.201901004R, 2019. 10.1096/fj.201901004r. Discussed on Sept. 27, 2019

Sierau S, Glaesmer H, Klucken T, Stalder T. Hair cortisol, lifetime traumatic experiences and psychopathology in unaccompanied refugee minors. Psychoneuroendocrinology 104: 191–194, 2019. 10.1016/j.psyneuen.2019.03.003. Discussed on Sept. 20, 2019

Tinsley GM, Moore ML, Graybeal AJ, Paoli A, Kim Y, Gonzales JU, Harry JR, VanDusseldorp TA, Kennedy DN, Cruz MR. Time-restricted feeding plus resistance training in active females: a randomized trial. Am J Clin Nutr 110: 628–640, 2019. 10.1093/ajcn/nqz126. Discussed on Sept. 20, 2019

Chagwedera DN, Ang QY, Bisanz JE, Leong YA, Ganeshan K, Cai J, Patterson AD, Turnbaugh PJ, Chawla A. Nutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass. Cell Metab 30: 364-373.e7, 2019. 10.1016/j.cmet.2019.05.002. Discussed on Sept. 13, 2019

Kogan M, Klempfner R, Lotan D, Wasserstrum Y, Goldenberg I, Segal G. Low ALT blood levels are associated with lower baseline fitness amongst participants of a cardiac rehabilitation program. J Exerc Sci Fit 16: 1–4, 2018. 10.1016/j.jesf.2017.11.002. Discussed on Sept. 6, 2019

Radford BN, Han VKM. Offspring from maternal nutrient restriction in mice show variations in adult glucose metabolism similar to human fetal growth restriction. J. Dev. Orig. Health Dis. (2018). 10.1017/S2040174418000983. Discussed on Sept. 6, 2019

Depner CM, Melanson EL, Eckel RH, Snell-Bergeon JK, Perreault L, Bergman BC, Higgins JA, Guerin MK, Stothard ER, Morton SJ, Wright KP. Ad libitum Weekend Recovery Sleep Fails to Prevent Metabolic Dysregulation during a Repeating Pattern of Insufficient Sleep and Weekend Recovery Sleep. Curr Biol 29: 957-967.e4, 2019. 10.1016/j.cub.2019.01.069. Discussed on Sept. 6, 2019

August 2019 Journal Club Articles

Huang T-Y, Goldsmith FR, Fuller SE, Simon J, Batdorf HM, Scott MC, Essajee NM, Brown JM, Burk DH, Morrison CD, Burke SJ, Collier JJ, Noland RC. Response of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive. 2019. 10.1249/MSS.0000000000002105. Discussed on Aug. 9, 2019

Lesage J, Del-Favero F, Leonhardt M, Louvart H, Maccari S, Vieau D, Darnaudery M. Prenatal stress induces intrauterine growth restriction and programmes glucose intolerance and feeding behaviour disturbances in the aged rat. J Endocrinol 181: 291–296, 2004. 10.1677/joe.0.1810291. Discussed on Aug. 9, 2019

Short SJ, Stalder T, Marceau K, Entringer S, Moog NK, Shirtcliff EA, Wadhwa PD, Buss C. Correspondence between hair cortisol concentrations and 30-day integrated daily salivary and weekly urinary cortisol measures. Psychoneuroendocrinology 71: 12–18, 2016. 10.1016/j.psyneuen.2016.05.007. Discussed on Aug. 2, 2019

Halberg N, Henriksen M, Söderhamn N, Stallknecht B, Ploug T, Schjerling P, Dela F. Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol 99: 2128–2136, 2005. 10.1152/japplphysiol.00683.2005. Discussed on Aug. 2, 2019

Youm Y-H, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D’Agostino D, Planavsky N, Lupfer C, Kanneganti T-DD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. The ketone metabolite b-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nat Med 21: 263–269, 2015. 10.1038/nm.3804. Discussed on Aug. 2, 2019

July 2019 Journal Club Articles

Ference BA, Ray KK, Catapano AL, Ference TB, Burgess S, Neff DR, Oliver-Williams C, Wood AM, Butterworth AS, Di Angelantonio E, Danesh J, Kastelein JJP, Nicholls SJ. Mendelian Randomization Study of ACLY and Cardiovascular Disease . N Engl J Med 380: 1033–1042, 2019. 10.1056/nejmoa1806747. Discussed on July 19, 2019

Chang CR, Francois ME, Little JP. Restricting carbohydrates at breakfast is sufficient to reduce 24-hour exposure to postprandial hyperglycemia and improve glycemic variability. Am J Clin Nutr 109: 1302–1309, 2019. 10.1093/ajcn/nqy261. Discussed on July 19, 2019

Guillaume M, Riant E, Fabre A, Raymond?Letron I, Buscato M, Davezac M, Tramunt B, Montagner A, Smati S, Zahreddine R, Palierne G, Valera M, Guillou H, Lenfant F, Unsicker K, Metivier R, Fontaine C, Arnal J, Gourdy P. Selective Liver Estrogen Receptor ? Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice. Hepatol Commun 3: 908–924, 2019. 10.1002/hep4.1363. Discussed on July 19, 2019

Zhang R, Ma H, Gao Y, Wu Y, Qiao Y, Geng A, Cai C, Han Y, Zeng YA, Liu X, Ge G. Th-POK regulates mammary gland lactation through mTOR-SREBP pathway. PLoS Genet 14: 1–23, 2018. 10.1371/journal.pgen.1007211. Discussed on July 19, 2019

Gillen JB, West DW, Williamson EP, Fung HJW, Moore DR. Low-Carbohydrate Training Increases Protein Requirements of Endurance Athletes. Med Sci Sport Exerc : 1, 2019. 10.1249/mss.0000000000002036. Discussed on July 12, 2019

Garcia-Leon MA, Peralta-Ramirez MI, Arco-Garcia L, Romero-Gonzalez B, Caparros-Gonzalez RA, Saez-Sanz N, Santos-Ruiz AM, Montero-Lopez E, Gonzalez A, Gonzalez-Perez R. Hair cortisol concentrations in a Spanish sample of healthy adults. PLoS One 13: 1–16, 2018. 10.1371/journal.pone.0204807. Discussed on July 12, 2019

June 2019 Journal Club Articles

Eskenazi B, Marks AR, Catalano R, Bruckner T, Toniolo PG. Low birthweight in New York city and upstate New York following the events of September 11th. Hum Reprod 22: 3013–3020, 2007. 10.1093/humrep/dem301. Discussed on June 14, 2019

Togo J, Hu S, Li M, Niu C, Speakman JR. Impact of dietary sucrose on adiposity and glucose homeostasis in C57BL/6J mice depends on mode of ingestion: Liquid or solid. Mol Metab : 1–11, 2019. 10.1016/j.molmet.2019.05.010. Discussed on June 14, 2019

Sinha R, Gu P, Hart R, Guarnaccia JB. Food craving, cortisol and ghrelin responses in modeling highly palatable snack intake in the laboratory. Physiol Behav 208: 112563, 2019. 10.1016/j.physbeh.2019.112563. Discussed on June 14, 2019

Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJY, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. A conserved NAD + binding pocket that regulates protein-protein interactions during aging. Science (80- ) 355: 1312–1317, 2017. 10.1126/science.aad8242. Discussed on June 7, 2019

Keleidari B, Mahmoudieh M, Mofrad RM, Shahabi S, Sheikhbahaei E. Gastroileostomy for controlling body weight and lipid profile: An experimental rat model. Obes Med 15: 100096, 2019. 10.1016/j.obmed.2019.100096. Discussed on June 7, 2019

Jia J, Dou P, Gao M, Kong X, Li C, Liu Z, Huang T. Assessment of Causal Direction Between Gut Microbiota-Dependent Metabolites and Cardiometabolic Health: A bi-Directional Mendelian Randomisation Analysis. Diabetes : db190153, 2019. 10.2337/db19-0153. Discussed on June 7, 2019

Cokorinos EC, Delmore J, Reyes AR, Albuquerque B, Kjøbsted R, Jørgensen NO, Tran JL, Jatkar A, Cialdea K, Esquejo RM, Meissen J, Calabrese MF, Cordes J, Moccia R, Tess D, Salatto CT, Coskran TM, Opsahl AC, Flynn D, Blatnik M, Li W, Kindt E, Foretz M, Viollet B, Ward J, Kurumbail RG, Kalgutkar AS, Wojtaszewski JFP, Cameron KO, Miller RA. Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice. Cell Metab 25: 1147-1159.e10, 2017. 10.1016/j.cmet.2017.04.010. Discussed on June 7, 2019

May 2019 Journal Club Articles

Yu H, Dilbaz S, Coßmann J, Hoang AC, Diedrich V, Herwig A, Harauma A, Hoshi Y, Moriguchi T, Landgraf K, Körner A, Lucas C, Brodesser S, Balogh L, Thuróczy J, Karemore G, Kuefner MS, Park EA, Rapp C, Travers JB, Röszer T. Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages. J Clin Invest 2019. 10.1172/JCI125646. Discussed on May 31, 2019

March 2019 Journal Club Articles

Perez-Garcia V, Fineberg E, Wilson R, et al. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018;555(7697):463-468. 10.1038/nature26002. Discussed on March 22, 2019

Ortiz LA, Quan A, Weinberg A, Baum M. Effect of prenatal dexamethasone on rat renal development. Kidney Int. 2001;59(5):1663-1669. 10.1046/j.1523-1755.2001.0590051663.x. Discussed on March 22, 2019

Gouvêa AL, Martinez CG, Kurtenbach E. Determining Maximal Muscle Strength in Mice. J Strength Cond Res. 2018;00(00):1. 10.1519/JSC.0000000000002777. Discussed on March 22, 2019

Hall KD. Ultra-processed diets cause excess calorie intake and weight gain: A one-month inpatient randomized controlled trial of ad libitum food intake. NutriXiv. 2019. 10.31232/osf.io/w3zh2. Discussed on March 22, 2019

Graham AM, Rasmussen JM, Entringer S, et al. Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors. Biol Psychiatry. 2019;85(2):172-181. doi:10.1016/j.biopsych.2018.06.023. 10.1016/j.biopsych.2018.06.023. Discussed on March 15, 2019

Wharfe MD, Mark PJ, Waddell BJ. Circadian variation in placental and hepatic clock genes in rat pregnancy. Endocrinology. 2011;152(9):3552-3560. doi:10.1210/en.2011-0081. 10.1210/en.2011-0081. Discussed on March 15, 2019

Pattison KL, Kraschnewski JL, Lehman E, et al. Breastfeeding initiation and duration and child health outcomes in the first baby study. Prev Med (Baltim). 2019;118(March 2018):1-6. doi:10.1016/j.ypmed.2018.09.020. 10.1016/j.ypmed.2018.09.020. Discussed on March 8, 2019

Weir T, Barbour LA, Johnson LK, et al. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018;9(1):1-12. doi:10.1038/s41467-018-06929-0. 10.1038/s41467-018-06929-0. Discussed on March 8, 2019

Høgild ML, Bak AM, Pedersen SB, et al. Growth hormone signaling and action in obese versus lean human subjects. Am J Physiol Metab. 2019;316(2):E333-E344. doi:10.1152/ajpendo.00431.2018. 10.1152/ajpendo.00431.2018. Discussed on March 1, 2019

Chen Z, He P, Ding X, Huang Y, Gu H, Ni X. PPAR? stimulates expression of L-type amino acid and taurine transporters in human placentas: The evidence of PPAR? regulating fetal growth. Sci Rep. 2015;5(December 2014):1-13. doi:10.1038/srep12650. 10.1038/srep12650. Discussed on March 1, 2019

Herrick K, Phillips DIW, Haselden S, et al. Maternal Consumption of a High-Meat , Low- Carbohydrate Diet in Late Pregnancy : Relation to Adult Cortisol Concentrations in the Offspring. 2003;88(8):3554-3560. doi:10.1210/jc.2003-030287. 10.1210/jc.2003-030287. Discussed on March 1, 2019

February 2019 Journal Club Articles

Mitchell SJ, Bernier M, Mattison JA, et al. Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories. Cell Metab. 2019;29(1):221-228.e3. doi:10.1016/j.cmet.2018.08.011. 10.1016/j.cmet.2018.08.011. Discussed on Feb. 22, 2019

Falduto MT, Czerwinski SM, Hickson RC. Glucocorticoid-induced muscle atrophy prevention by exercise in fast-twitch fibers. J Appl Physiol. 2017;69(3):1058-1062. doi:10.1152/jappl.1990.69.3.1058. 10.1152/jappl.1990.69.3.1058. Discussed on Feb. 22, 2019

Ear PH, Chadda A, Gumusoglu SB, et al. Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring. Cell Rep. 2019;26(4):969-983.e4. doi:10.1016/j.celrep.2019.01.007. 10.1016/j.celrep.2019.01.007. Discussed on Feb. 22, 2019

Ebbeling CB, Feldman HA, Klein GL, et al. Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial. Bmj. 2018;363:k4583. doi:10.1136/BMJ.K4583. 10.1136/BMJ.K4583. Discussed on Feb. 15, 2019

Rouleau G, Karpati G, Carpenter S, Soza M, Prescott S, Holland P. Glucocorticoid excess induces preferential depletion of myosin in denervated skeletal muscle fibers. Muscle Nerve. 1987;10(5):428-438. doi:10.1002/mus.880100509. 10.1002/mus.880100509. Discussed on Feb. 8, 2019

Kim W, Deik A, Gonzalez C, et al. Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling. Cell Metab. 2019;0(0):1-15. doi:10.1016/j.cmet.2018.12.023. 10.1016/j.cmet.2018.12.023. Discussed on Feb. 8, 2019

Nishiumi S, Yoshida M, Kawano Y, et al. b-Hydroxybutyrate Protects Hepatocytes Against Endoplasmic Reticulum Stress in a Sirtuin 1-Independent Manner. Arch Biochem Biophys. 2019;663(January):220-227. doi:10.1016/j.abb.2019.01.020. 10.1016/j.abb.2019.01.020. Discussed on Feb. 8, 2019

January 2019 Journal Club Articles

Patel, S. et al. GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans. Cell Metab. 1–12 (2019). 10.1016/j.cmet.2018.12.016. Discussed on Jan. 25, 2019

Niu, X. T. et al. Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring. Psychoneuroendocrinology 102, 128–138 (2019). 10.1016/j.psyneuen.2018.12.003. Discussed on Jan. 25, 2019

Barbazanges, A., Piazza, P. V., Le Moal, M. & Maccari, S. Maternal Glucocorticoid Prenatal Stress Secretion Mediates Effects of. J. Neurosci. 16, 3943–3949 (1996). 10.1523/JNEUROSCI.16-12-03943.1996. Discussed on Jan. 25, 2019

Dalle, H. et al. Adipocyte glucocorticoid receptor deficiency promotes adipose tissue expandability and improves the metabolic profile under corticosterone exposure. Diabetes 1–13 (2018). 10.2337/db17-1577. Discussed on Jan. 25, 2019

October 2018 Journal Club Articles

Gilson, H. et al. Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 148, 452–460 (2007). 10.1210/en.2006-0539. Discussed on Oct. 12, 2018

Louden, E., Chi, M. M. & Moley, K. H. Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance. Reproduction 136, 335–344 (2008). 10.1530/REP-08-0161. Discussed on Oct. 12, 2018

González-García, I. et al. Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep. 25, 413–423.e5 (2018). 10.1016/j.celrep.2018.09.038. Discussed on Oct. 12, 2018

Meoli, L. et al. Non-alcoholic Fatty Liver Disease and Gastric Bypass Surgery Regulate Serum And Hepatic Levels of Pyruvate Kinase Isoenzyme M2. Am. J. Physiol. Endocrinol. Metab. 20, 20 (2018). 10.1152/ajpendo.00296.2017. Discussed on Oct. 12, 2018

Akkad, H. et al. Vamorolone treatment improves skeletal muscle outcome in a critical illness myopathy rat model. Acta Physiol. e13172 (2018). doi:10.1111/apha.13172 10.1111/apha.13172. Discussed on Oct. 12, 2018

Cirulli, E. T. et al. Profound Perturbation of the Metabolome in Obesity Is Associated with Health Risk. Cell Metab. 1–13 (2018). doi:10.1016/j.cmet.2018.09.022 10.1016/j.cmet.2018.09.022. Discussed on Oct. 12, 2018

August 2018 Journal Club Articles

Muñiz Pedrogo, D. A. et al. Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet. Mayo Clin. Proc. 93, 1104–1110 (2018). 10.1016/j.mayocp.2018.02.019. Discussed on Aug. 17, 2018

Ben-Zvi, D. et al. Time-Dependent Molecular Responses Differ between Gastric Bypass and Dieting but Are Conserved Across Species. Cell Metab. 28, 310–323.e6 (2018). 10.1016/j.cmet.2018.06.004. Discussed on Aug. 17, 2018

Macedo, A. G. et al. Time-course changes of catabolic proteins following muscle atrophy induced by dexamethasone. Steroids 107, 30–36 (2016). 10.1016/j.steroids.2015.12.016. Discussed on Aug. 17, 2018

Krishnan, S. et al. A randomized controlled-feeding trial based on the Dietary Guidelines for Americans on cardiometabolic health indexes. Am. J. Clin. Nutr. 108, 266–278 (2018). 10.1093/ajcn/nqy113. Discussed on Aug. 17, 2018

Langdown, M. L. & Sugden, M. C. Enhanced placental GLUT1 and GLUT3 expression in dexamethasone-induced fetal growth retardation. Mol. Cell. Endocrinol. 185, 109–117 (2001). 10.1016/S0303-7207(01)00629-3. Discussed on Aug. 17, 2018

Danese, A. et al. Adverse Childhood Experiences and Adult Risk Factors for Age-Related Disease. Arch. Pediatr. Adolesc. Med. 163, 1135–1143 (2009). 10.1001/archpediatrics.2009.214. Discussed on Aug. 17, 2018

Gokulakrishnan, G., Estrada, I. J., Sosa, H. A. & Fiorotto, M. L. In utero glucocorticoid exposure reduces fetal skeletal muscle mass in rats independent of effects on maternal nutrition. AJP Regul. Integr. Comp. Physiol. 302, R1143–R1152 (2012). 10.1152/ajpregu.00466.2011. Discussed on Aug. 3, 2018

Sutton, E. F. et al. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 27, 1212–1221.e3 (2018). 10.1016/j.cmet.2018.04.010. Discussed on Aug. 3, 2018

Reynolds, C. M., Vickers, M. H., Harrison, C. J., Segovia, S. A. & Gray, C. Maternal high fat and/or salt consumption induces sex specific inflammatory and nutrient transport in the rat placenta. Physiol. Rep. 3, 1–10 (2015). 10.14814/phy2.12399. Discussed on Aug. 3, 2018

Zemva, J. et al. Central FoxO3a and FoxO6 expression is downregulated in obesity induced diabetes but not in aging. Exp. Clin. Endocrinol. Diabetes 120, 340–350 (2012). 10.1055/s-0031-1297970. Discussed on Aug. 3, 2018

Taylor, R. et al. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for ? Cell Recovery. Cell Metab. 0, 1–10 (2018). 10.1016/j.cmet.2018.07.003. Discussed on Aug. 3, 2018

July 2018 Journal Club Articles

Hopkins BD, Pauli C, Du X, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018;560(7719):499-503. 10.1038/s41586-018-0343-4. Discussed on July 20, 2018

Short, K. R., Bigelow, M. L. & Nair, K. S. Short-term prednisone use antagonizes insulin’s anabolic effect on muscle protein and glucose metabolism in young healthy people. AJP Endocrinol. Metab. 297, E1260–E1268 (2009). 10.1152/ajpendo.00345.2009. Discussed on July 20, 2018

Miller, T., Mull, S., Aragon, A. A., Krieger, J. & Schoenfeld, B. J. Resistance training combined with diet decreases body fat while preserving lean mass independent of resting metabolic rate: A randomized trial. Int. J. Sport Nutr. Exerc. Metab. 28, 46–54 (2018). 10.1123/ijsnem.2017-0221. Discussed on July 20, 2018

Seelig, E. et al. Metformin prevents metabolic side effects during systemic glucocorticoid treatment. Eur. J. Endocrinol. 176, 349–358 (2017). 10.1530/EJE-16-0653. Discussed on July 20, 2018

June 2018 Journal Club Articles

d’Avignon, D. A. et al. Hepatic ketogenic insufficiency reprograms hepatic glycogen metabolism and the lipidome. JCI Insight 3, (2018). 10.1172/JCI.INSIGHT.99762. Discussed on June 29, 2018

Singh, A., Zapata, R. C., Pezeshki, A., Reidelberger, R. D. & Chelikani, P. K. Inulin fiber dose-dependently modulates energy balance, glucose tolerance, gut microbiota, hormones and diet preference in high-fat fed male rats. J. Nutr. Biochem. 1072–1074 (2018). doi:10.1016/j.jnutbio.2018.05.017 10.1016/j.jnutbio.2018.05.017. Discussed on June 29, 2018

Song, L. et al. Prenatal high-fat diet alters placental morphology, nutrient transporter expression, and mtorc1 signaling in rat. Obesity 25, 909–919 (2017). 10.1002/oby.21821. Discussed on June 29, 2018

Hasan, A. U. et al. PPAR? Activation Mitigates Glucocorticoid Receptor-Induced Excessive Lipolysis in Adipocytes via Homeostatic Crosstalk. J. Cell. Biochem. 1–26 (2017). doi:10.1002/jcb.26631 10.1002/jcb.26631. Discussed on June 29, 2018

Brassard, D. et al. Saturated fats from butter but not from cheese increase HDL-Mediated cholesterol efflux capacity from J774 macrophages in men and women with abdominal obesity. J. Nutr. 148, 573–580 (2018). 10.1093/jn/nxy014. Discussed on June 15, 2018

Altmäe, S. et al. Maternal pre-pregnancy obesity is associated with altered placental transcriptome. PLoS One 12, 1–17 (2017). 10.1371/journal.pone.0169223. Discussed on June 15, 2018

Sengupta, S., Peterson, T. R., Laplante, M., Oh, S. & Sabatini, D. M. MTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 468, 1100–1106 (2010). 10.1038/nature09584. Discussed on June 15, 2018

Tran, C. M. et al. Rapamycin blocks induction of the thermogenic program in white adipose tissue. Diabetes 65, 1–35 (2016). 10.2337/db15-0502. Discussed on June 15, 2018

Zhang, M., Sun, W., Qian, J. & Tang, Y. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid beta-oxidation and ketogenesis via activating XBP1 signaling in liver. Redox Biol. 16, 87–96 (2018). 10.1016/j.redox.2018.01.013. Discussed on June 8, 2018

Guertin, D. A. et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell 11, 859–871 (2006). 10.1016/j.devcel.2006.10.007. Discussed on June 8, 2018

Luukkonen, P. K. et al. Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. Diabetes Care dc180071 (2018). 10.2337/dc18-0071. Discussed on June 8, 2018

May 2018 Journal Club Articles

Li, Y., Moretto-Zita, M., Leon-Garcia, S. & Parast, M. M. P63 inhibits extravillous trophoblast migration and maintains cells in a cytotrophoblast stem cell-like state. Am. J. Pathol. 184, 3332–3343 (2014). 10.1016/j.ajpath.2014.08.006. Discussed on May 25, 2018

Burke, S. J. et al. Oral Corticosterone Administration Reduces Insulitis but Promotes Insulin Resistance and Hyperglycemia in Male Nonobese Diabetic Mice. Am. J. Pathol. 187, 614–626 (2017). 10.1016/j.ajpath.2016.11.009. Discussed on May 25, 2018

White, P. J. et al. The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase. Cell Metab. 0, 1–13 (2018). 10.1016/j.cmet.2018.04.015. Discussed on May 25, 2018

Liang, X. H. et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402, 672–675 (1999). 10.1038/scibx.2008.460. Discussed on May 11, 2018

Stanford, K. I. et al. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 27, 1111–1120.e3 (2018). 10.1016/j.cmet.2018.03.020. Discussed on May 11, 2018

Lancaster, G. I. et al. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism. Cell Metab. 1–15 (2018). doi:10.1016/j.cmet.2018.03.014 10.1016/j.cmet.2018.03.014. Discussed on May 4, 2018

Bahrami-Nejad, Z. et al. A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation. Cell Metab. 27, 854–868.e8 (2018). 10.1016/j.cmet.2018.03.012. Discussed on May 4, 2018

April 2018 Journal Club Articles

Khera, A. V. et al. Genome - wide polygenic score to identify a monogenic risk - equivalent for coronary disease. bioRxiv (2017). doi:10.1101/218388 10.1101/218388. Discussed on April 20, 2018

Ahmadi, M. A., Zar, A., Krustrup, P. & Ahmadi, F. Testosterone and cortisol response to acute intermittent and continuous aerobic exercise in sedentary men. Sport Sci. Health 14, 1–8 (2017). 10.1007/s11332-017-0399-9. Discussed on April 20, 2018

He, M. et al. Placental findings associated with maternal obesity at early pregnancy. Pathol. Res. Pract. 212, 282–287 (2016). 10.1016/j.prp.2016.01.006. Discussed on April 20, 2018

Ravnskov, U. et al. Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: A systematic review. BMJ Open 6, 1–8 (2016). 10.1136/bmjopen-2015-010401. Discussed on April 20, 2018

Hudgins, L. C. et al. Young, healthy South Asians have enhanced lipogenic sensitivity to dietary sugar. Clin. Endocrinol. (Oxf). 86, 361–366 (2017). 10.1111/cen.13293. Discussed on April 6, 2018

Cameron, M., Camic, C. L., Doberstein, S., Erickson, J. L. & Jagim, A. R. The acute effects of a multi-ingredient pre-workout supplement on resting energy expenditure and exercise performance in recreationally active females. J. Int. Soc. Sports Nutr. 15, 1 (2018). 10.1186/s12970-017-0206-7. Discussed on April 6, 2018

Lin, Y., Zhuo, Y., Fang, Z. F., Che, L. Q. & Wu, D. Effect of maternal dietary energy types on placenta nutrient transporter gene expressions and intrauterine fetal growth in rats. Nutrition 28, 1037–1043 (2012). 10.1016/j.nut.2012.01.002. Discussed on April 6, 2018

Benson, T. W. et al. A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome. Lab. Invest. (2018). doi:10.1038/s41374-018-0038-3 10.1038/s41374-018-0038-3. Discussed on April 6, 2018

Shariatpanahi, Z. V., Shariatpanahi, M. V., Shahbazi, S., Hossaini, A. & Abadi, A. Effect of Ramadan fasting on some indices of insulin resistance and components of the metabolic syndrome in healthy male adults. Br. J. Nutr. 100, 147–151 (2008). 10.1017/S000711450787231X. Discussed on April 6, 2018

March 2018 Journal Club Articles

Pereira, M. G. et al. Comparative analysis of muscle hypertrophy models reveals divergent gene transcription profiles and points to translational regulation of muscle growth through increased mTOR signaling. Front. Physiol. 8, 1–11 (2017). 10.3389/fphys.2017.00968. Discussed on March 23, 2018

Heerwagen, M. J. R. et al. Placental lipoprotein lipase activity is positively associated with newborn adiposity. Placenta 64, 53–60 (2018). 10.1016/j.placenta.2018.03.001. Discussed on March 23, 2018

Thuzar, M. et al. Glucocorticoids suppress brown adipose tissue function in humans: A double-blind placebo-controlled study. Diabetes, Obes. Metab. 840–848 (2017). 10.1111/dom.13157. Discussed on March 23, 2018

Shimobayashi, M. et al. Insulin resistance causes inflammation in adipose tissue. J. Clin. Invest. (2018). 10.1172/JCI96139. Discussed on March 23, 2018

Anway M, D; Cupp A, Uzumcu S, Skinner M, K M. Epigenetic Transgenerational Action of Endocrine Disruptors and Male Fertility. Science 2005;308:1466–9. 10.1126/science.1108190. Discussed on March 16, 2018

Wang Y, Liu Z, Han Y, Xu J, Huang W, Li Z. Medium Chain Triglycerides enhances exercise endurance through the increased mitochondrial biogenesis and metabolism. PLoS One 2018;13:1–11. 10.1371/journal.pone.0191182. Discussed on March 16, 2018

Miyajima K, Teoh S, Yamashiro H, et al. Effects on Glycemic Control in Impaired Wound Healing in Spontaneously Diabetic Torii (SDT) Fatty Rats. Med Arch 2018;72:4. 10.5455/medarh.2018.72.4-8. Discussed on March 16, 2018

Zhang P, Zhu D, Zhang Y, et al. Synergetic Effects of Prenatal and Postnatal High Sucrose Intake on Glucose Tolerance and Hepatic Insulin Resistance in Rat Offspring. Mol Nutr Food Res 2018;1700771:1700771. 10.1002/mnfr.201700771. Discussed on March 16, 2018

Poff AM, Ari C, Seyfried TN, D’Agostino DP. The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer. PLoS One 2013;8. 10.1371/journal.pone.0065522. Discussed on March 16, 2018

February 2018 Journal Club Articles

Hasan AU, Ohmori K, Hashimoto T, et al. PPAR? Activation Mitigates Glucocorticoid Receptor-Induced Excessive Lipolysis in Adipocytes via Homeostatic Crosstalk. J Cell Biochem 2017:1–26. 10.1002/jcb.26631. Discussed on Feb. 23, 2018

Jang C, Hui S, Lu W, et al. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab 2018;27:351–361.e3. 10.1016/j.cmet.2017.12.016. Discussed on Feb. 23, 2018

Mayer C, Acosta-Martinez M, Dubois SL, et al. Timing and completion of puberty in female mice depend on estrogen receptor -signaling in kisspeptin neurons. Proc Natl Acad Sci 2010;107:22693–22698. 10.1073/pnas.1012406108. Discussed on Feb. 16, 2018

Hu Y, Semova I, Sun X, et al. Fructose and glucose regulate mammalian target of rapamycin complex 1 and can activate lipogenic gene expression via distinct pathways. J Biol Chem 2017;293:jbc.M117.782557. 10.1074/jbc.M117.782557. Discussed on Feb. 16, 2018

Chowdhury EA, Richardson JD, Tsintzas K, Thompson D, Betts JA. Postprandial Metabolism and Appetite Do Not Differ between Lean Adults that Eat Breakfast or Morning Fast for 6 Weeks. J Nutr 2018;148:13–21. 10.1093/jn/nxx004. Discussed on Feb. 16, 2018

Antonio J, Ellerbroek A, Evans C, Silver T, Peacock CA. High protein consumption in trained women: bad to the bone? J Int Soc Sports Nutr 2018;15:6. 10.1186/s12970-018-0210-6. Discussed on Feb. 16, 2018

Rosqvist F, Iggman D, Kullberg J, et al. Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans. Diabetes 2014;63:2356–2368. 10.2337/db13-1622. Discussed on Feb. 16, 2018