Dave Bridges

Position
Associate Professor, Department of Nutritional Sciences, University of Michigan since 2022-09-01. (2 years, 3 months).
Assistant Professor, Department of Nutritional Sciences, University of Michigan from 2016-06-01 to 2022-08-31. (June 1, 2016 to Aug. 31, 2022)
Assistant Professor, Department of Pediatrics, Le Bonheur Children's Hospital from 2013-04-22 to 2016-05-31. (April 22, 2013 to May 31, 2016)
Assistant Professor, Department of Physiology, University of Tennesee Health Science Center from 2013-04-21 to 2016-05-31. (April 21, 2013 to May 31, 2016)
Degrees
B.Sc. (Biological Sciences, University of Calgary).
Ph.D. (Biological Sciences, University of Calgary).
Email
davebrid@umich.edu
Phone
7347641266
ORCID Identification Number
0000-0002-5334-972X
Bio
My team wants to understand the molecular networks that lie at the intersection between metabolism and health. I did my undergraduate and doctoral training in Biochemistry at the University of Calgary, in Calgary, Alberta, Canada followed by a fellowship with Dr. Alan Saltiel at the University of Michigan. During that time we used several model systems including yeast, flies and mice to elucidate a variety of novel aspects of metabolic regulation. My team studies the molecular, cellular and physiological changes associated with obesity. We are particularly interested in the role of the central nutrient responsive protein kinase mTORC1, how it is altered in weight gain and how its activation affects obesity related co-morbidities. With a better understanding of the molecular mechanisms underlying obesity, we hope to better prevent and treat obesity in the future.
Social Media
Photo of Dave Bridges

Publications

  1. Molly Mulcahy, Noura El Habbal, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice 2024. Endocrinology Full Text Details.
  2. Laura Saslow, Alison O'Brien, Kaitlyn Raymond, Hovig Bayandorian, Deanna Marriott, Judith Moskowitz, Jennifer Daubenmier, Dave Bridges, Cody Cousineau and Dina Griauzde. Feasibility and acceptability of an online multicomponent very low-carbohydrate intervention in young adult women with obesity: a pilot study 2024. Pilot and Feasibility Studies 10(1):102 Full Text Details.
  3. Cody Cousineau, Detrick Snyder, JeAnna Redd, Sophia Turner, Treyton Carr and Dave Bridges. Reduced beta-hydroxybutyrate disposal after ketogenic diet feeding in mice 2024. bioRxiv Full Text Details. Preprint
  4. Michael Saul, Elizabeth Litkowski, Niran Hadad, Amy Dunn, Stephanie Boas, Jon Wilcox, Julia Robbins, Yiyang Wu, Vivek Philip, Gennefer Merrihew, Jea Park, Philip De Jager, Dave Bridges, Vilas Menon, David Bennett, Timothy Hohman, Michael MacCoss and Catherine Kaczorowski. Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population 2024. bioRxiv Full Text Details. Preprint
  5. Cody Cousineau, Kaelin Loftus, Gary Churchill and Dave Bridges. Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice 2023. FEBS Open Biology 14(3):426-433 Full Text Details.
  6. Molly Mulcahy, Noura El Habbal, Detrick Snyder, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. Gestational Early-Time Restricted Feeding Results in Sex-Specific Glucose Intolerance in Adult Male Mice 2023. Journal of Obesity Full Text Details.
  7. Avnee Kumar, Chitra Parthasarathy, Hallie Prescott, Scott Denstaedt, Michael Newstead, Dave Bridges, Angela Bustamante, Kanakadurga Singer and Benjamin Singer. Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction 2023. Hepatology Communications 7(9):e0210 Full Text Details.
  8. Katherine Kim, Mita Varghese, Haijing Sun, Simin Abrishami, Emily Bowers, Dave Bridges, Jennifer Meijer, Kanakadurga Singer and Brigid Gregg. The influence of maternal high fat diet during lactation on offspring hematopoietic priming 2023. Endocrinology Full Text Details.
  9. Zach Carlson, Hannah Hafner, Noura El Habbal, Emma Harman, Stephanie Liu, Nathalie Botezatu, Masa Alharastani, Cecelia Rivet, Holly Reynolds, Nyahon Both, Haijing Sun, Dave Bridges and Brigid Gregg. Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology 2022. Journal of Mammary Gland Biology and Neoplasia 27(1):1-18 Full Text Details.
  10. Hannah Hafner, Molly Mulcahy, Zach Carlson, Philip Hartley, Haijing Sun, Maria Westerhoff, Nathan Qi, Dave Bridges and Brigid Gregg. Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment 2021. Frontiers in Nutrition 8:759690 Full Text Details.
  11. Peter Mancuso, Jeffrey Curtis, Anne Weitzel, Cameron Griffin, Benjamin Bouchard, Christine Freeman, Dave Bridges and Kanakadurga Singer. Diet-induced obesity in mice impairs host defense against Klebsiella pneumonia in vivo and glucose transport and bactericidal functions in neutrophils in vitro 2022. American Journal of Physiology: Lung Cellular and Molecular Physiology 322(1):L116-L128 Full Text Details.
  12. Noura El Habbal, Allison Meyer, Hannah Hafner, JeAnna Redd, Zach Carlson, Molly Mulcahy, Brigid Gregg and Dave Bridges. Activation of Adipocyte mTORC1 Increases Milk Lipids in a Mouse Model of Lactation BioRxiv Full Text Details. Preprint
  13. Laura Gunder, Innocence Harvey, JeAnna Redd, Carol Davis, Ayat AL-Tamimi, Susan Brooks and Dave Bridges. Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice 2020. Biomedicines 8(10):420 Full Text Details.
  14. Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi and Brigid Gregg. Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner 2020. American Journal of Physiology - Endocrinology & Metabolism 318(5):E600-E612 Full Text Details.
  15. Elana Elkin, Dave Bridges, Sean Harris and Rita Loch-Caruso. Exposure to the trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine causes compensatory changes to macronutrient utilization and energy metabolism in placental HTR-8/SVneo cells 2020. Chemical Research in Toxicology 33(6):1339–1355 Full Text Details.
  16. Scott Ochsner, David Abraham, Kirt Martin, Wei Ding, Apollo McOwiti, Wasula Kankanamge, Zichen Wang, Kaitlyn Andreano, Ross Hamilton, Yue Chen, Angelica Hamilton, Marin Gantner, Michael Dehart, Shijing Qu, Susan Hilsenbeck, Lauren Becnel, Dave Bridges, Avi Ma'ayan, Janice Huss, Fabio Stossi, Charles Foulds, Anastasia Kralli, Donald McDonnell and Neil McKenna. The Signaling Pathways Project, an integrated 'omics knowledgebase for mammalian cellular signaling pathways 2019. Scientific Data 6(1):252 Full Text Details.
  17. Elana Elkin, Dave Bridges and Rita Loch-Caruso. The trichloroethylene metabolite S-(1,2-dichlorovinyl)-L-cysteine induces progressive mitochondrial dysfunction in HTR-8/SVneo trophoblasts 2019. Toxicology 427(July):152283 Full Text Details.
  18. Erin Stephenson, JeAnna Redd, Detrick Snyder, Quynh Tran, Binbin Lu, Matthew Peloquin, Molly Mulcahy, Innocence Harvey, Kaleigh Fisher, Joan Han, Nathan Qi, Alan Saltiel and Dave Bridges. Skeletal Muscle mTORC1 Activation Increases Energy Expenditure and Reduces Longevity in Mice 2019. bioRxiv Full Text Details. Preprint
  19. Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy Barnes, Gabrielle Steinl, Nicole Patterson, Christopher Altheim, Naveen Sharma, Ken Inoki, Gregory Cartee, Dave Bridges, Lei Yin and Diane Fingar. AMPK directly activates mTORC2 to promote cell survival during acute energetic stress 2019. Science Signaling 11(12):585 Full Text Details.
  20. John Bissler, Fahad Zadjali, Dave Bridges, Aristotelis Astrindis, Sharon Barone, Ying Yao, JeAnna Redd, Brian Siroky, Yanqing Wang, Joel Finley, Michael Rusniak, Heinz Baumann, Kamyar Zahedi, Kenneth Gross and Manoocher Soleimani. Tuberous sclerosis complex exhibits a new renal cystogenic mechanism. 2019. Physiological Reports 7(2):e13983 Full Text Details.
  21. Liam McAllan, Kristen Maynard, Alisha Kardian, Amanda Stayton, Shelby Fox, Erin Stephenson, Clint Kinney, Noor Alshibli, Charles Gomes, Joseph Pierre, Michelle Puchowicz, Dave Bridges, Keri Martinowich and Joan Han. Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice 2018. American Journal of Physiology - Endocrinology and Metabolism 315(6):E1168-E1184 Full Text Details.
  22. Matthew Wilson, Amanda Sen, Dave Bridges, D. Turgeon, Dean Brenner, William Smith, Mack Ruffin and Zora Djuric. Higher baseline expression of the PTGS2 gene and greater decreases in total colonic fatty acid content predict greater decreases in colonic prostaglandin-E2 concentrations after dietary supplementation with w-3 fatty acids 2018. Prostaglandins, Leukotrienes and Essential Fatty Acids Full Text Details.
  23. Qingming Dong, Michael Keufner, Xiong Deng, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Sex-specific differences in hepatic steatosis in obese spontaneously hypertensive (SHROB) rats. 2018. Biology of Sex Differences 9(1):40 Full Text Details.
  24. Innocence Harvey, Erin Stephenson, JeAnna Redd, Quynh Tran, Irit Hochberg, Nathan Qi and Dave Bridges. Glucocorticoid-Induced Metabolic Disturbances are Exacerbated in Obese Male Mice. 2018. Endocrinology 159(6):1-13 Full Text Details.
  25. Nora Urraca, Kevin Hope, A. Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh Tran, Silva Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges and Lawrence Reiter. Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons 2018. Molecular Autism 9(6): Full Text Details.
  26. Michael Keufner, Kevin Pham, JeAnna Redd, Erin Stephenson, Innocence Harvey, Xiong Deng, Dave Bridges, Eric Boilard, Marshal Elam and Edwards Park. Secretory phospholipase A2 group IIA (PLA2G2A) modulates insulin sensitivity and metabolism. 2017. Journal of Lipid Research Full Text Details.
  27. Suriyan Ponnusamy, Ryan Sullivan, Dahui You, Nadeem Zafar, Chuan He Yang, Thirumagal Thiyagarajan, Daniel Johnson, Maron Barrett, Nikki Koehler, Mayra Star, Erin Stephenson, Dave Bridges, Stephania Cormier, Lawrence Pfeffer and Ramesh Narayanan. Androgen Receptor Agonists Increase Lean Mass, Improve Cardiopulmonary Functions, and Extend Survival in Preclinical Models of Duchenne Muscular Dystrophy 2017. Human Molecular Genetics Full Text Details.
  28. Dave Bridges Weight loss effects of Methotrexate and Cyclophosphamide. 2017. Oncotarget 8(3):5640 Full Text Details.
  29. Suriyan Ponnusamy, Quynh Tran, Thirumagal Thiyagarajan, Duane Miller, Dave Bridges and Ramesh Narayanan. An Estrogen Receptor b-Selective Agonist Inhibits Non-Alcoholic Steatohepatitis (NASH) in Preclinical Models by Regulating Bile Acid and Xenobiotic Receptors 2017. Experimental Biology and Medicine 242(6):606-616 Full Text Details.
  30. Suriyan Ponnusamy, Quynh Tran, Innocence Harvey, Heather Smallwood, Thirumagal Thiyagarajan, Souvik Banerjee, Daniel Johnson, James Dalton, Ryan Sullivan, Duane Miller, Dave Bridges and Ramesh Narayanan. Pharmacologic activation of estrogen receptor-beta; increases mitochondrial function, energy expenditure, and brown adipose tissue. 2017. FASEB Journal 31(1):266-281 Full Text Details.
  31. Alysse Charrier, Li Wang, Erin Stephenson, Siddharth Gantha, Chih-wei Ko, Colleen Croninger, Dave Bridges and David Buchner. Zinc finger protein 407 overexpression upregulates PPAR-target gene expression and improves glucose homeostasis in mice. 2016. American Journal of Physiology - Endocrinology and Metabolism 311(5):E869-E880 Full Text Details.
  32. Erin Stephenson, Alyse Ragauskas, Sridhar Jaligama, JeAnna Redd, Jyothi Parvathareddy, Matthew Peloquin, Jordy Saravia, Joan Han, Stephania Cormier and Dave Bridges. Exposure to environmentally persistent free radicals during gestation lowers energy expenditure and impairs skeletal muscle mitochondrial function in 2016. American Journal of Physiology - Endocrinology And Metabolism 310(11):E1003-E1015 Full Text Details.
  33. Qingming Dong, Francesco Giorgianni, Sarka Beranova-Giorgianni, Xiong Deng, Robert O'Meally, Dave Bridges, Edwards Park, Marshal Elam and Rajendra Raghow. Glycogen synthase kinase-3 mediated phosphorylation of serine 73 targets sterol response element binding protein-1c (SREBP-1c) for proteasomal degrada 2015. Bioscience Reports 36(1):e00284 Full Text Details.
  34. Nora Urraca, R. Menon, I. El-Iyachi, Sarita Goorha, Colleen Valdez, Quynh Tran, Reese Scroggs, G. Miranda-Carboni , Martin Donaldson, Dave Bridges and Lawrence Reiter. Characterization of neurons from immortalized dental pulp stem cells for the study of neurogenetic disorders. 2015. Stem Cell Research 15(3):722-30 Full Text Details.
  35. C. Song, K. Ghafoor, H. Ghafoor, N. Kahn, S. Thirunavukkarasu, B. Jennings, A. Estes, S. Zaidi, Dave Bridges, Patrick Tso, F. Gonzalez and K. Malik. Cytochrome P450 1B1 Contributes to the Development of Atherosclerosis and Hypertension in Apolipoprotein E-Deficient Mice. 2016. Hypertension 67(1):206-13 Full Text Details.
  36. Xiong Deng, Qingming Dong, Dave Bridges, Rajendra Raghow, Edwards Park and Marshal Elam. Docosahexaenoic Acid Inhibits Proteolytic Processing of Sterol Regulatory Element-binding Protein-1c (SREBP-1c) via Activation of AMP-activated Kinase 2015. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 185(12):1521-9 Full Text Details.
  37. Irit Hochberg, Innocence Harvey, Quynh Tran, Erin Stephenson, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene expression changes in subcutaneous adipose tissue due to Cushing's disease. 2015. Journal of Molecular Endocrinology 55(2):81-94 Full Text Details.
  38. Irit Hochberg, Quynh Tran, Ariel Barkan, Alan Saltiel, William Chandler and Dave Bridges. Gene Expression Signature in Adipose Tissue of Acromegaly Patients. 2015. PLOS One 10(6):e0129359 Full Text Details.
  39. Izzy Hatfield, Innocence Harvey, Erika Yates, JeAnna Redd, Lawrence Reiter and Dave Bridges. The role of TORC1 in muscle development in Drosophila. 2015. Scientific Reports 5:9676 Full Text Details.
  40. David Buchner, Alysse Charrier, Ethan Srinivasan, Li Wang, Michelle Paulsen, Mats Ljungman, Dave Bridges and Alan Saltiel. Zinc Finger Protein 407 (ZFP407) Regulates Insulin-Stimulated Glucose Uptake and Glucose Transporter 4 (Glut4) mRNA. 2015. The Journal of biological chemistry 290(10):6376-86 Full Text Details.
  41. Dave Bridges and Alan Saltiel. Phosphoinositides: Key Modulators of Energy Metabolism 2014. Biochimica and Biophysica Acta - Molecular and Cell Biology of Lipids 1851(6):857-866 Full Text Details.
  42. Qingming Dong, Francesco Giorgianni, Xiong Deng, Sarka Beranova-Giorgianni, Dave Bridges, Edwards Park, Rajendra Raghow and Marshal Elam. Phosphorylation of Sterol Regulatory Element Binding Protein-1a by Protein Kinase A (PKA) Regulates Transcriptional Activity 2014. Biochemical and Biophysical Research Communications 449(4):449-54 Full Text Details.
  43. Anne Morrow, Mohsen Amir Alipour, Dave Bridges, Zemin Yao, Alan Saltiel and Jonathan Lee. The lipid kinase PI4KIIIbeta is highly expressed in breast tumours and activates Akt in cooperation with Rab11a. 2014. Molecular Cancer Research 12(10):1492-508 Full Text Details.
  44. Natsuko JIn, Kai Mao, Yui Jin, Gela Tevadze, Emily Kauffman, Sujin Park, Dave Bridges, Robbie Loewith, Alan Saltiel, Daniel Klionsky and Lois Weisman. Roles for PI(3,5)P2 in nutrient sensing through TORC1 2014. Molecular Biology of the Cell 25(7):1171-85 Full Text Details.
  45. Matthew Peloquin and Dave Bridges. Weight Loss in Response to Food Deprivation Predicts The Extent of Diet Induced Obesity in C57BL/6J Mice bioRxiv Full Text Details. Preprint
  46. Binbin Lu, Dave Bridges, Yemen Yang, Kaleigh Fisher, Alan Cheng, Louise Chang, Zhuoxian Meng, Jiande Lin, Michael Downes, Ruth Yu, Christopher Liddle, Ronald Evans and Alan Saltiel. Metabolic Crosstalk: molecular links between glycogen and lipid metabolism in obesity. 2014. Diabetes 63(9):2935-48 Full Text Details.
  47. Tsukasa Suzuki, Dave Bridges, Daisuke Nakada, Georgios Skiniotis, Sean Morrison, Jiande Lin, Alan Saltiel and Ken Inoki. Inhibition of AMPK catabolic action by GSK3. 2013. Molecular cell 50(3):407-19 Full Text Details.
  48. Sergey Zolov, Dave Bridges, Yanling Zhang, Wei-Wei Li, Ellen Riehle, Rakesh Verma, Guy Lenk, Kimber Converso-Baran, Thomas Weide, Roger Albin, Alan Saltiel, Miriam Meisler, Mark Russell and Lois Weisman. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. 2012. Proceedings of the National Academy of Sciences of the United States of America 109(43):17472-7 Full Text Details.
  49. Dave Bridges and Alan Saltiel. Phosphoinositides in insulin action and diabetes. 2012. Current topics in microbiology and immunology 362:61-85 Full Text Details.
  50. Dave Bridges, Louise Chang, Irfan Lodhi, Natalie Clark and Alan Saltiel. TC10 is regulated by caveolin in 3T3-L1 adipocytes. 2012. PLOS One 7(8):e42451 Full Text Details.
  51. Dave Bridges, Kaleigh Fisher, Sergey Zolov, Tingting Xiong, Ken Inoki, Lois Weisman and Alan Saltiel. Rab5 proteins regulate activation and localization of target of rapamycin complex 1. 2012. The Journal of biological chemistry 287(25):20913-21 Full Text Details.
  52. Dave Bridges, Jing-Tyan Ma, Sujin Park, Ken Inoki, Lois Weisman and Alan Saltiel. Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. 2012. Molecular biology of the cell 23(15):2955-62 Full Text Details.
  53. Bernat Baeza-Raja, Pingping Li, Natacha Le Moan, Benjamin Sachs, Christian Schachtrup, Dimitrios Davalos, Eirini Vagena, Dave Bridges, Choel Kim, Alan Saltiel, Jerrold Olefsky and Katerina Akassoglou. p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity. 2012. Proceedings of the National Academy of Sciences of the United States of America 109(15):5838-43 Full Text Details.
  54. Irfan Lodhi, Dave Bridges, Shian-Huey Chiang, Yanling Zhang, Alan Cheng, Lynn Geletka, Lois Weisman and Alan Saltiel. Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. 2008. Molecular biology of the cell 19(7):2718-28 Full Text Details.
  55. Dave Bridges, Justin MacDonald, Brian Wadzinski and Greg Moorhead. Identification and characterization of D-AKAP1 as a major adipocyte PKA and PP1 binding protein. 2006. Biochemical and biophysical research communications 346(1):351-7 Full Text Details.
  56. Dave Bridges and Greg Moorhead. 14-3-3 proteins: a number of functions for a numbered protein (2005 Update). 2005. Science's STKE : signal transduction knowledge environment 2005(296):re10 Full Text Details.
  57. Dave Bridges and Greg Moorhead. 14-3-3 proteins: a number of functions for a numbered protein. 2004. Science's STKE : signal transduction knowledge environment 2004(242):re10 Full Text Details.
  58. Dave Bridges, Marie Fraser and Greg Moorhead. Cyclic nucleotide binding proteins in the Arabidopsis thaliana and Oryza sativa genomes. 2005. BMC bioinformatics 6:6 Full Text Details.
  59. Greg Moorhead, Sarah Meek, Pauline Douglas, Dave Bridges, Catherine Smith, Nick Morrice and Carol MacKintosh. Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays. 2003. European journal of biochemistry 270(6):1356-62 Full Text Details.
  60. Hue Tran, Dave Bridges, Annegret Ulke and Greg Moorhead. Detection of multiple splice variants of the nuclear protein phosphatase 1 regulator sds22 in rat liver nuclei. 2002. Biochemistry and cell biology 80(6):811-5 Full Text Details.
  61. Darin Fogg, Dave Bridges, Kitty Cheung, Geetha Kassam, Nolan Filipenko, Kyu-Sil Choi, Sandra Fitzpatrick, Michael Nesheim and David Waisman. The p11 subunit of annexin II heterotetramer is regulated by basic carboxypeptidase. 2002. Biochemistry 41(15):4953-61 Full Text Details.