Regulation of Mammary Physiology

Project Summary

How does the mammary gland respond to nutritional, and physiological signals from the mother and child. We have been investigating this in collaboration with the Gregg Lab in the Departments of Pediatrics and Nutritional Sciences using both mouse and human models.

Who is Working on This?

Dave Bridges

Associate Professor, Department of Nutritional Sciences, University of Michigan since 2022-09-01

Brigid Gregg

Assistant Professor, Department of Nutritional Sciences, University of Michigan since 2011-07-01

Jiayin Liu

MS Student, Department of Nutritional Sciences, University of Michigan from 2023-01-01 to 2024-04-30

Publications

What have we published on this topic?

Molly Mulcahy, Noura El Habbal, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice 2024. Endocrinology Full Text Details.

Katherine Kim, Mita Varghese, Haijing Sun, Simin Abrishami, Emily Bowers, Dave Bridges, Jennifer Meijer, Kanakadurga Singer and Brigid Gregg. The influence of maternal high fat diet during lactation on offspring hematopoietic priming 2023. Endocrinology Full Text Details.

Zach Carlson, Hannah Hafner, Noura El Habbal, Emma Harman, Stephanie Liu, Nathalie Botezatu, Masa Alharastani, Cecelia Rivet, Holly Reynolds, Nyahon Both, Haijing Sun, Dave Bridges and Brigid Gregg. Short Term Changes in Dietary Fat Content and Metformin Treatment During Lactation Impact Milk Composition and Mammary Gland Morphology 2022. Journal of Mammary Gland Biology and Neoplasia 27(1):1-18 Full Text Details.

Hannah Hafner, Molly Mulcahy, Zach Carlson, Philip Hartley, Haijing Sun, Maria Westerhoff, Nathan Qi, Dave Bridges and Brigid Gregg. Lactational High Fat Diet in Mice Causes Insulin Resistance and NAFLD in Male Offspring Which Is Partially Rescued by Maternal Metformin Treatment 2021. Frontiers in Nutrition 8:759690 Full Text Details.

Noura El Habbal, Allison Meyer, Hannah Hafner, JeAnna Redd, Zach Carlson, Molly Mulcahy, Brigid Gregg and Dave Bridges. Activation of Adipocyte mTORC1 Increases Milk Lipids in a Mouse Model of Lactation BioRxiv Full Text Details. Preprint

Zach Carlson, Hannah Hafner, Molly Mulcahy, Kaylie Bullock, Allen Zhu, Dave Bridges, Ernesto Bernal-Mizrachi and Brigid Gregg. Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner 2020. American Journal of Physiology - Endocrinology & Metabolism 318(5):E600-E612 Full Text Details.