Bridges Lab Posts

Blog Posts

1. Nutrition Teaching Resources by Dave Bridges on March 9, 2024.
2. Serum Calcium and Cholesterol Are Associated in Mice by Dave Bridges on Feb. 18, 2024.
3. #METPHYS2020 Presentation by Dave Bridges on March 23, 2020.
4. Our Favorite Papers of 2017 by Dave Bridges on Jan. 25, 2018.
5. Our Favorite Papers of 2016 by Dave Bridges on Dec. 30, 2016.
6. Thoughts on Interim Research Products by Dave Bridges on Nov. 19, 2016.
7. The Bridges Lab at TOS 2016 by Dave Bridges on Oct. 30, 2016.
8. Paper on Cushing's disease wins award from the Society for Endocrinology by Dave Bridges on Sept. 10, 2016.
9. Lab Protocols Site by Dave Bridges on July 23, 2016.
10. Validation of RNAseq Experiments by qPCR? by Dave Bridges on July 23, 2016.
11. Early life glucocorticoid exposure can cause long-term risk of obesity by Innocence Harvey on Jan. 27, 2016.
12. Our Favorite Papers of 2015 by Dave Bridges on Dec. 26, 2015.
13. Bridges Lab Publication Policy by Dave Bridges on Sept. 13, 2015.
14. Why do we use the negative binomial distribution for RNAseq? by Dave Bridges on Aug. 30, 2015.
15. The Effects of Glucocorticoids on Adipose Tissue by Innocence Harvey on Aug. 21, 2015.
16. New Paper on Effects of Acromegaly on Adipose Tissue by Dave Bridges on June 30, 2015.
17. Lab Data and Resource Sharing Plan by Dave Bridges on June 29, 2015.
18. The Story Behind the Paper: The role of TORC1 in muscle development in Drosophila by Dave Bridges on April 26, 2015.
19. Reviews for Peloquin and Bridges Manuscript by Dave Bridges on May 23, 2014.
20. The Story Behind the Paper: Fasting Induced Weight Loss Predicts Weight Gain by Dave Bridges on April 19, 2014.

Journal Club Summaries

Owen Vaughn, Theresa Powell and Thomas Jansson. Glucocorticoid regulation of amino acid transport in primary human trophoblast cells 2019. Journal of Molecular Endocrinology 63(4):239-248 Full Text Our Thoughts Details.

Rachel Perry, Jon Resch, Amelia Douglass, Joseph Madara, Aviva Rabin-Court, Hakan Kucukdereli, Chen Wu, Joongyu Song, Bradford Lowell and Gerald Shulman. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents 2019. Proceedings of the National Academy of Sciences 116(27):13670-13679 Full Text Our Thoughts Details.

Vincente Perez-Garcia, Elena Fineberg, Robert Wilson, Alexander Murray, Cecilia Icoresi Mazzeo, Catherine Tudor, Arnold Sienerth, Jacqueline White, Elizabeth Tuck, Edward Ryder, Diane Gleason, Himsha Beltran, Emma Siragher, Hannah Wardle-Jones, Nicole Staudt, Neha Wali, John Collins, Stefan Geyer, Elisabeth Busch-Nentwich, Antonella Galli, James Smith, Elizabeth Robertson, David Adams, Wolfgang Weninger, Timothy Mohun and Myriam Hemberger. Placentation defects are highly prevalent in embryonic lethal mouse mutants 2018. Nature 555(7697):463-468 Full Text Our Thoughts Details.

Morten Lyng Hogild, Ann Mosegaard Bak, Steen Bonlokke Pedersen, Jorgen Rungby, Jan Frystyk, Niels Moller, Niels Jessen and Jens Otto Lunde Jorgensen. Growth hormone signaling and action in obese versus lean human subjects 2019. American Journal of Physiology - Endocrinology and Metabolism 316(2):E333-E344 Full Text Our Thoughts Details.

Benjamin Hopkins, Chantal Pauli, Xing Du, Diana Wang, Xiang Li, David Wu, Solomon Amadiume, Marcus Goncalves, Cindy Hodakoski, Mark Lundquist, Rohan Bareja, Yan Ma, Emily Harris, Andrea Sboner, Himsha Beltran, Siddhartha Mukherjee and Lewis Cantley. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors 2018. Nature 560(7719):499-503 Full Text Our Thoughts Details.

Meiyuan Zhang, Weilan Sun, Jin Qian and Yan Tang. Fasting exacerbates hepatic growth differentiation factor 15 to promote fatty acid beta-oxidation and ketogenesis via activating XBP1 signaling in liver 2018. Redox Biology 16(February):87-96 Full Text Our Thoughts Details.

Graeme Lancaster, Katherine Langley, Nils Anton Berglund, Helene Kammoun, Saskia Reibe, Emma Estevez, Jacquelyn Weir, Natalie Mellett, Gerard Pernes, James Conway, Man Lee, Paul Timpson, Andrew Murphy, Seth Masters, Steve Gerondakis, Nenad Bartonicek, Dominik Kaczorowski, Marcel Dinger, Peter Meikle, Peter Bond and Mark Febbraio. Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism 2018. Cell Metabolism Full Text Our Thoughts Details.

Choolson Jang, Sheng Hui, Wenyun Lu, Alexis Cowan, Raphael Morscher, Gina Lee, Wei Liu, Gregory Tesz, Morris Birnbaum and Joshua Rabinowitz. The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids 2018. Cell Metabolism 27(2):351-361 Full Text Our Thoughts Details.

Naresh Bal, Santosh Maurya, Danesh Sopariwala, Sanjaya Sahoo, Subash Gupta, Sana Shaikh, Meghna Pant, Leslie Rowland, Eric Bombardier, Sanjeewa Goonasekera, Russel Tupling, Jeffery Molkentin and Muthu Periasamy. Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. 2012. Nature Medicine 18(19):1575-9 Full Text Our Thoughts Details.

Kevin Hall, Thomas Bemis, Robert Brychta, Kong Chen, Amber Courvillle, Emma Crayner, Stephanie Goodwin, Juen Guo, Lillian Howard, Nicolas Knuth, Bernard Miller, Carla Prado, Maria Siervo, Monica Skarulis, Mary Walter, Peter Walter and Laura Yannai. Calorie for Calorie, Dietary Fat Restriction Results in More Body Fat Loss than Carbohydrate Restriction in People with Obesity 2015. Cell Metabolism 22(3):427-436 Full Text Our Thoughts Details.

Yumiko Oishi, Ichiro Manabe, Kazuyuki Tobe, Mitsuru Ohsugi, Tetsuya Kubota, Katsuhito Fujiu, Koji Maemura, Naoto Kubota, Takashi Kadowaki and Ryozo Nagai. SUMOylation of Kruppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. 2008. Nature Medicine 14(6):656-666 Full Text Our Thoughts Details.

Andrew Shin, Martin Fasshauer, Nika Filatova, Linus Grundell, Elizabeth Zielinski, Jian-Ying Zhou, Thomas Scherer, Claudia Lindtner, Amanda Lapworth, Olga Ilkayeva, Uwe Knippschild, Anna Wolf, Ludger Shedja, Kevin Grove, Richard Smith, Wei-Jun Qian, Chrisopher Lynch, Christopher Newgard and Christophe Buettner. Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism. 2014. Cell metabolism S1550-4131(14):00400-8 Full Text Our Thoughts Details.

O. Nelson, Jingxiang Huang, Heiko Jansen, Elizabeth Galbreath, Kurt Morgenstern, Jamie Gehring, Kimberly Rigano, Jae Lee, Jianhua Gong, Adam Shaywitz, Chantal Vella, Charles Robbins and Kevin Corbit. Grizzly Bears Exhibit Augmented Insulin Sensitivity while Obese Prior to a Reversible Insulin Resistance during Hibernation 2014. Cell Metabolism 20(2):376-82 Full Text Our Thoughts Details.

Robert Koza, Larissa Nikonova, Jessica Hogan, Jong-Seop Rim, Tamra Mendoza, Christopher Faulk, Jihad Skaf and Leslie Kozak. Changes in gene expression foreshadow diet-induced obesity in genetically identical mice. 2006. PLOS Genetics 2(5):e81 Full Text Our Thoughts Details.

Xiaoyuan Xu, Ambar Grijalva, Alicja Skowronski, Marco van Eijk, Mireille J Serlie and Anthony Ferrante. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. 2014. Cell metabolism 18(6):816-30 Full Text Our Thoughts Details.

Hui Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel Squillace, Chin-Lee Wu and Brendan Manning. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. 2009. PLOS One 4(7):e6189 Full Text Our Thoughts Details.

Alexander von Wilamowitz-Moellendorff, Roger Hunter, Mar Garcia-Rocha, Li Kang, Iliana Lopez-Soldado, Louise Lantier, Kashyap Patel, Mark Peggie, Carlos Martinez-Pons, Martin Voss, Joaquim Calbo, Patricia Cohen, David Wasserman, Joan Guinovart and Kei Sakamoto. Glucose-6-Phosphate-Mediated Activation of Liver Glycogen Synthase Plays a Key Role in Hepatic Glycogen Synthesis. 2013. Diabetes Full Text Our Thoughts Details.

Christine Longuet, Elaine Sinclair, Adriano Maida, Laurie Baggio, Marlena Maziarz, Maureen Charron and Daniel Drucker. The glucagon receptor is required for the adaptive metabolic response to fasting. 2008. Cell Metabolism 8(5):359-71 Full Text Our Thoughts Details.

Subhash Katewa, Fabio Demontis, Marysia Kolipinski, Alan Hubbard, Matthew Gill, Norbert Perrimon, Simon Melov and Pankaj Kapahi. Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster. 2012. Cell metabolism 16(1):97-103 Full Text Our Thoughts Details.

Shunsuke Takasuga, Yasuo Horie, Junko Sasaki, Ge-Hong Sun-Wada, Nobuyuki Kawamura, Ryota Iizuka, Katsunori Mizuno, Satoshi Eguchi, Satoshi Kofuji, Hirotaka Kimura, Masakazu Yamazaki, Chihoko Horie, Eri Odanaga, Yoshiko Sato, Shinsuke Chida, Kenji Kontani, Akihiro Harada, Akihiro Katada, Akira Suzuki, Yoh Wada, Hirohide Ohnishi and Takehiko Sasaki. Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine. 2013. Proceedings of the National Academy of Sciences of the United States of America 110(5):1726-31 Full Text Our Thoughts Details.