Welcome to the Bridges Lab

We are interested in the factors which cause obesity, the mechanisms by which this happens and how interventions in this pathway can alleviate obesity or its associated diseases. Our group uses a variety of model systems including cell culture, yeast, flies and mice to understand the signaling and metabolic pathways which are involved in these processes. We then use modern molecular biology, genetic and pharmacological tools to manipulate and learn more about the physiology of obesity.

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Recent Publications

Molly Mulcahy, Noura El Habbal, JeAnna Redd, Haijing Sun, Brigid Gregg and Dave Bridges. GDF15 knockout does not substantially impact perinatal body weight or neonatal outcomes in mice 2024. Endocrinology Full Text Details.

Laura Saslow, Alison O'Brien, Kaitlyn Raymond, Hovig Bayandorian, Deanna Marriott, Judith Moskowitz, Jennifer Daubenmier, Dave Bridges, Cody Cousineau and Dina Griauzde. Feasibility and acceptability of an online multicomponent very low-carbohydrate intervention in young adult women with obesity: a pilot study 2024. Pilot and Feasibility Studies 10(1):102 Full Text Details.

Cody Cousineau, Detrick Snyder, JeAnna Redd, Sophia Turner, Treyton Carr and Dave Bridges. Reduced beta-hydroxybutyrate disposal after ketogenic diet feeding in mice 2024. bioRxiv Full Text Details. Preprint

Michael Saul, Elizabeth Litkowski, Niran Hadad, Amy Dunn, Stephanie Boas, Jon Wilcox, Julia Robbins, Yiyang Wu, Vivek Philip, Gennefer Merrihew, Jea Park, Philip De Jager, Dave Bridges, Vilas Menon, David Bennett, Timothy Hohman, Michael MacCoss and Catherine Kaczorowski. Hippocampus Glutathione S Reductase Potentially Confers Genetic Resilience to Cognitive Decline in the AD-BXD Mouse Population 2024. bioRxiv Full Text Details. Preprint

Cody Cousineau, Kaelin Loftus, Gary Churchill and Dave Bridges. Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice 2023. FEBS Open Biology 14(3):426-433 Full Text Details.

Click here for a full list of papers.

Blog Posts

Comments on Papers

Journal Club Discussions

November 2024 Journal Club Articles

Huang S, Chen J, Cui Z, Ma K, Wu D, Luo J, Li F, Xiong W, Rao S, Xiang Q, Shi W, Song T, Deng J, Yin Y, Tan C. Lachnospiraceae-derived butyrate mediates protection of high fermentable fiber against placental inflammation in gestational diabetes mellitus. Sci Adv. 2023 Nov 3;9(44):eadi7337. doi: 10.1126/sciadv.adi7337. Epub 2023 Nov 3. PMID: 37922350; PMCID: PMC10624355. 10.1126/sciadv.adi7337. Discussed on Nov. 11, 2024

October 2024 Journal Club Articles

Machado H, Hofer P, Zechner R, Smith TK, Figueiredo LM. Adipocyte lipolysis protects mice against Trypanosoma brucei infection. Nat Microbiol. 2023 Nov;8(11):2020-2032. doi: 10.1038/s41564-023-01496-7. Epub 2023 Oct 12. PMID: 37828246; PMCID: PMC10627827. https://doi.org/10.1038/s41564-023-01496-7. Discussed on Oct. 28, 2024

September 2024 Journal Club Articles

Sonsalla MM, Babygirija R, Johnson M, Cai S, Cole M, Yeh CY, Grunow I, Liu Y, Vertein D, Calubag MF, Trautman ME, Green CL, Rigby MJ, Puglielli L, Lamming DW. Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. Geroscience. 2024 Sep 14. doi: 10.1007/s11357-024-01337-3. Epub ahead of print. PMID: 39271570. 10.1007/s11357-024-01337-3. Discussed on Sept. 30, 2024

Bolognini, D., Halgren, A., Lou, R.N. et al. Recurrent evolution and selection shape structural diversity at the amylase locus. Nature (2024). 10.1038/s41586-024-07911-1. Discussed on Sept. 16, 2024

April 2024 Journal Club Articles

Crujeiras AB, Izquierdo AG, Primo D, Milagro FI, Sajoux I, Jácome A, Fernandez-Quintela A, Portillo MP, Martínez JA, Martinez-Olmos MA, de Luis D, Casanueva FF. Epigenetic landscape in blood leukocytes following ketosis and weight loss induced by a very low calorie ketogenic diet (VLCKD) in patients with obesity. Clin Nutr. 2021 Jun;40(6):3959-3972. doi: 10.1016/j.clnu.2021.05.010. Epub 2021 May 21. PMID: 34139469. 10.1016/j.clnu.2021.05.010. Discussed on April 5, 2024

Click here for a full list of journal club articles.