PCR Amplification of DNA: Difference between revisions

mNo edit summary
Line 15: Line 15:


*Run PCR Program.  Normally use touchdown PCR ('''DAVETD''') as follows:
*Run PCR Program.  Normally use touchdown PCR ('''DAVETD''') as follows:
#1 min at 94
:#1 min at 94
#30s at 65
:#30s at 65
#2 min/kb at 72
:#2 min/kb at 72
#30s at 94
:#30s at 94
#30s at 63 then -0.5/cycle
:#30s at 63 then -0.5/cycle
#2 min/kb at 72
:#2 min/kb at 72
#Repeat steps 4-6 28 times
:#Repeat steps 4-6 28 times
#30s at 94
:#30s at 94
#30s at 45
:#30s at 45
#11 min at 72
:#11 min at 72
#hold at 4 until ready
:#Hold at 4 until ready
*Purify PCR product if necessary using Qiagen kit (Add 5x PB)
*Purify PCR product if necessary using Qiagen kit (Add 5x PB)