Preparing Cell Lysates: Difference between revisions

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Materials
==Materials==


RIPA Buffer (for 10mL lysis buffer)
===RIPA Buffer (for 10mL lysis buffer)===
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|-Tris pH7.4 !! 50mM !! 500uL
|-Na Deoxycholate !! 0.25% !! 250uL
|-NP-40 !! 1% !! 1mL
|-NaCl !! 150mM !! 375uL
|-EDTA !! 1mM !! 20uL
|-NaVO3 !! 1mM !! 100uL
|-NaF !! 1mM !! 20uL
|-Protease Inhibitors !! 1 tab


Tris pH7.4 50mM 500uL
==Basic Protocol==
 
Na Deoxycholate 0.25% 250uL
 
NP-40 1% 1mL
 
NaCl 150mM 371uL
 
EDTA 1mM 20uL
 
NaVO3 1mM 100uL
 
NaF 1mM 20uL
 
Protease Inhibitors 1 tab
 
Basic Protocol
# Stimulate cells if necessary
# Stimulate cells if necessary
# Wash cells 2x1mL with ice cold PBS -/- and aspirate
# Wash cells 2x1mL with ice cold PBS -/- and aspirate